Zipaquirá in the context of Cajicá

The Spanish conquest of the Muisca took place from 1537 to 1540. The Muisca were the inhabitants of the central Andean highlands of Colombia before the arrival of the Spanish conquistadors. They were organised in a loose confederation of different rulers; the psihipqua of Muyquytá, with his headquarters in Funza, the hoa of Hunza, the iraca of the sacred City of the Sun Sugamuxi, the Tundama of Tundama, and several other independent caciques. The most important rulers at the time of the conquest were psihipqua Tisquesusa, hoa Eucaneme, iraca Sugamuxi and Tundama in the northernmost portion of their territories. The Muisca were organised in small communities of circular enclosures (ca in their language Muysccubbun; literally "language of the people"), with a central square where the bohío of the cacique was located. They were called "Salt People" because of their extraction of salt in various locations throughout their territories, mainly in Zipaquirá, Nemocón, and Tausa. For the main part self-sufficient in their well-organised economy, the Muisca traded with the European conquistadors valuable products as gold, tumbaga (a copper-silver-gold alloy), and emeralds with their neighbouring indigenous groups. In the Tenza Valley, to the east of the Altiplano Cundiboyacense where the majority of the Muisca lived, they extracted emeralds in Chivor and Somondoco. The economy of the Muisca was rooted in their agriculture with main products maize, yuca, potatoes, and various other cultivations elaborated on elevated fields (in their language called tá). Agriculture had started around 3000 BCE on the Altiplano, following the preceramic Herrera Period and a long epoch of hunter-gatherers since the late Pleistocene. The earliest archaeological evidence of inhabitation in Colombia, and one of the oldest in South America, has been found in El Abra, dating to around 12,500 years BP.

The main part of the Muisca civilisation was concentrated on the Bogotá savanna, a flat high plain in the Eastern Ranges of the Andes, far away from the Caribbean coast. The savanna was an ancient lake, that existed until the latest Pleistocene and formed a highly fertile soil for their agriculture. The Muisca were a deeply religious civilisation with a polytheistic society and an advanced astronomical knowledge, which was represented in their complex lunisolar calendar. Men and women had specific and different tasks in their relatively egalitarian society; while the women took care of the sowing, preparation of food, the extraction of salt, and the elaboration of mantles and pottery, the men were assigned to harvesting, warfare, and hunting. The guecha warriors were tasked with the defence of the Muisca territories, mainly against their western neighbours; the Muzo ("Emerald People") and the bellicose Panche. To impress their enemies, the Muisca warriors wore mummies of important ancestors on their backs, while fighting. In their battles, the men used spears, poisoned arrows, and golden knives.

Nemocón is a municipality and town of Colombia in the Central Savanna Province, part of the department of Cundinamarca. Nemocón, famous for its salt mine, was an important village in the Muisca Confederation, the country in the central Colombian Andes before the arrival of the Spanish.

The municipality is situated in the northern part of the Bogotá savanna, part of the Altiplano Cundiboyacense with its urban centre at an altitude of 2,585 metres (8,481 ft) and 65 kilometres (40 mi) from the capital Bogotá. Nemocón is the northeasternmost municipality of the Metropolitan Area of Bogotá and the Bogotá River originates close to Nemocón. The median temperature of Nemocón is 12.8 °C. The municipality borders Tausa in the north, Zipaquirá and Gachancipá in the south, Suesca in the east, and Cogua in the west.

El Abra is the name given to an extensive archeological site, located in the valley of the same name. El Abra is situated in the east of the municipality Zipaquirá extending to the westernmost part of Tocancipá in the department of Cundinamarca, Colombia. The several hundred metres long series of rock shelters is in the north of the Bogotá savanna on the Altiplano Cundiboyacense, Eastern Ranges of the Colombian Andes at an altitude of 2,570 metres (8,430 ft). The rock shelter and cave system is one of the first evidences of human settlement in the Americas, dated at 12,400 ± 160 years BP. The site was used by the hunter-gatherers of the Late Pleistocene epoch.

This article describes the warfare of the Muisca. The Muisca inhabited the Tenza and Ubaque valleys and the Altiplano Cundiboyacense, the high plateau of the Colombian Eastern Ranges of the Andes in the time before the Spanish conquest. Their society was mainly egalitarian with little difference between the elite class (caciques) and the general people. The Muisca economy was based on agriculture and trading raw materials like cotton, coca, feathers, sea snails and gold with their neighbours. Called "Salt People", they extracted salt from brines in Zipaquirá, Nemocón and Tausa to use for their cuisine and as trading material.

Being mostly traders and farmers, the Muisca also had a structure of combatants, called guecha warriors. Between the northern and southern parts of the Muisca Confederation, battles were fought where the zipa, ruling over the Bogotá savanna in the south and the zaque of Hunza in the north contested for control over terrains. The leaders of the communities fought with their warriors. The main enemy of the Muisca were the Panche people who inhabited the area to the west of the Altiplano in the hills leading to the Magdalena River. Fortifications of guecha warriors, a privileged class in their society, were built in the border region with the Panche. The guecha warriors were armed with blowpipes, spears, clubs, and slings; and defended themselves with long shields and thick multi-layered cotton mantles. Battles in the history of the Muisca are described around Chocontá (~1490) and Pasca around 1470. When the Spanish conquistadors entered the Muisca Confederation in March 1537 after a long, deadly and sterunous expedition from Santa Marta at the Caribbean coast, they found little resistance of the Muisca, except in later battles against the Tundama ruling over the northernmost area around Duitama. The Spanish who already had conquered the Muisca and founded Bogotá, used the guecha warriors to submit the Panche in the Battle of Tocarema on August 20, 1538.