Zipa in the context of Muisca warfare

The Spanish conquest of the Muisca took place from 1537 to 1540. The Muisca were the inhabitants of the central Andean highlands of Colombia before the arrival of the Spanish conquistadors. They were organised in a loose confederation of different rulers; the psihipqua of Muyquytá, with his headquarters in Funza, the hoa of Hunza, the iraca of the sacred City of the Sun Sugamuxi, the Tundama of Tundama, and several other independent caciques. The most important rulers at the time of the conquest were psihipqua Tisquesusa, hoa Eucaneme, iraca Sugamuxi and Tundama in the northernmost portion of their territories. The Muisca were organised in small communities of circular enclosures (ca in their language Muysccubbun; literally "language of the people"), with a central square where the bohío of the cacique was located. They were called "Salt People" because of their extraction of salt in various locations throughout their territories, mainly in Zipaquirá, Nemocón, and Tausa. For the main part self-sufficient in their well-organised economy, the Muisca traded with the European conquistadors valuable products as gold, tumbaga (a copper-silver-gold alloy), and emeralds with their neighbouring indigenous groups. In the Tenza Valley, to the east of the Altiplano Cundiboyacense where the majority of the Muisca lived, they extracted emeralds in Chivor and Somondoco. The economy of the Muisca was rooted in their agriculture with main products maize, yuca, potatoes, and various other cultivations elaborated on elevated fields (in their language called tá). Agriculture had started around 3000 BCE on the Altiplano, following the preceramic Herrera Period and a long epoch of hunter-gatherers since the late Pleistocene. The earliest archaeological evidence of inhabitation in Colombia, and one of the oldest in South America, has been found in El Abra, dating to around 12,500 years BP.

The main part of the Muisca civilisation was concentrated on the Bogotá savanna, a flat high plain in the Eastern Ranges of the Andes, far away from the Caribbean coast. The savanna was an ancient lake, that existed until the latest Pleistocene and formed a highly fertile soil for their agriculture. The Muisca were a deeply religious civilisation with a polytheistic society and an advanced astronomical knowledge, which was represented in their complex lunisolar calendar. Men and women had specific and different tasks in their relatively egalitarian society; while the women took care of the sowing, preparation of food, the extraction of salt, and the elaboration of mantles and pottery, the men were assigned to harvesting, warfare, and hunting. The guecha warriors were tasked with the defence of the Muisca territories, mainly against their western neighbours; the Muzo ("Emerald People") and the bellicose Panche. To impress their enemies, the Muisca warriors wore mummies of important ancestors on their backs, while fighting. In their battles, the men used spears, poisoned arrows, and golden knives.

Hernán Pérez de Quesada, sometimes spelled as Quezada, (c. 1515 – 1544) was a Spanish conquistador. Second in command of the army of his elder brother, Gonzalo Jiménez de Quesada, Hernán was part of the first European expedition towards the inner highlands of the Colombian Andes. The harsh journey, taking almost a year and many deaths, led through the modern departments Magdalena, Cesar, Santander, Boyacá, Cundinamarca and Huila of present-day Colombia between 1536 and 1539 and, without him, Meta, Caquetá and Putumayo of Colombia and northern Peru and Ecuador between 1540 and 1542.

Hernán founded Sutatausa, Cundinamarca, and aided in the conquest of various indigenous groups, such as the Chimila, Muisca, Panche, Lache, U'wa, Sutagao and others. Under the command of Hernán Pérez de Quesada the last independent Muisca ruler; hoa Quiminza was publicly decapitated. As second in command under his brother, in the previous years psihipquias Tisquesusa and Sagipa and Tundama of Duitama had suffered a similar fate. After returning from his expeditions to the south reaching Quito, where he reunited with his younger brother Francisco, both De Quesadas went back to Santafé de Bogotá. Hernán was tried and imprisoned there for the murders of the Muisca rulers by the governor of the capital of the New Kingdom of Granada. In 1544, en route to Cartagena with his brother Francisco, their ship was hit by lightning off the coast of Cabo de la Vela in the Caribbean Sea killing Hernán and Francisco and wounding several other conquistadors.

Bacatá (Chibcha: Muyquytá or Muequetá) is the name given to the main settlement of one of the Muisca Confederations on the Bogotá savanna. It mostly refers to an area, rather than an individual village, although the name is also found in texts referring to the modern settlement of Funza, in the centre of the savanna. Bacatá was the main seat of the zipa, the ruler of the Bogotá savanna and adjacent areas. The name of the Colombian capital, Bogotá, is derived from Bacatá, but founded as Santafe de Bogotá in the western foothills of the Eastern Hills in a different location than the original settlement Bacatá, west of the Bogotá River, eventually named after Bacatá as well.

The word is a combination of the Chibcha words bac, ca and tá, and means "(enclosure) outside the farmfields", referring to the rich agricultural lands of the Sabana Formation on the Bogotá savanna. Bacatá was submitted to the Spanish Empire by the conquistadors led by Gonzalo Jiménez de Quesada on April 20, 1537. Santafe de Bogotá, the capital of the New Kingdom of Granada, was formally founded on August 6, 1538. The last zipa of an independent Bacatá was Tisquesusa, who died after being stabbed by a Spanish soldier. His brother, Sagipa, succeeded him and served as last zipa under Spanish rule.

Tisquesusa, also spelled Thisquesuza, Thysquesuca or Thisquesusha, referred to in the earliest sources as Bogotá, the Elder, (died Facatativá, 1537) was the fourth and last independent ruler (psihipqua) of Muyquytá, main settlement of the southern Muisca between 1514 and his death in 1537. The Spanish pronunciation of his name brought about the Colombian capital Bogotá. Tisquesusa was the ruler of the southern Muisca Confederation at the time of the Spanish conquest of the Muisca, when the troops led by Gonzalo Jiménez de Quesada and his brother entered the central Andean highlands.

Quemuenchatocha or Quimuinchateca (named in the earliest sources Eucaneme) (Hunza, 1472–Ramiriquí, 1538) was the second-last hoa of Hunza, currently known as Tunja, as of 1490. He was the ruler of the northern Muisca when the Spanish conquistadores arrived in the Muisca highlands. His contemporary enemy psihipquas of the southern Muisca were successively Nemequene and Bogotá.

Sugamuxi (died 1539) was the last iraca; cacique of the sacred City of the Sun Suamox. Sugamuxi, presently called Sogamoso, was an important city in the religion of the Muisca who inhabited the Altiplano Cundiboyacense in the times before the Spanish conquistadors reached the central highlands of the Colombian Andes. Fellow Muisca rulers of other territories within the Muisca Confederation were Tundama in Tundama, zaque Aquiminzaque in Hunza and zipa Sagipa in Bacatá.

The Muisca inhabited the Altiplano Cundiboyacense in the Colombian Andes before the arrival of the Spanish and were an advanced civilisation. They mummified the higher social class members of their society, mainly the zipas, zaques, caciques, priests and their families. The mummies would be placed in caves or in dedicated houses ("mausoleums") and were not buried.

Many mummies from the Chibcha-speaking indigenous groups have been found to date, mainly from the Muisca, Lache and Guane. In 1602 the early Spanish colonisers found 150 mummies in a cave near Suesca, that were organised in a scenic circular shape with the mummy of the cacique in the centre of the scene. The mummies were surrounded by cloths and pots. In 2007 the mummy of a baby was discovered in a cave near Gámeza, Boyacá, together with a small bowl, a pacifier and cotton cloths. The process of mummification continued into the colonial period. The youngest mummies have been dated to the second half of the 18th century.