The River Nene (/ˈnɛn/ or /ˈniːn/) flows through the counties of Northamptonshire, Cambridgeshire, Norfolk and Lincolnshire in eastern England, into The Wash in the North Sea. It flows largely northeast from its sources in Arbury Hill in Northamptonshire to its mouth at Lutton Marsh. The Nene and its tributaries drain an area of about 2,270 square kilometres (880 sq mi), with a population of 750,000.
The Nene's main tributaries include the River Ise, Wootton Brook, Willow Brook, and Harper's Brook. At 105 miles (169 km) long, it is the tenth-longest river in the United Kingdom, and is tidal for 45 kilometres (28 mi) up to Dog-in-a-Doublet sluice, near Peterborough.