Wile E. Coyote and the Road Runner in the context of "Chuck Jones"

Physical comedy is a form of comedy focused on manipulation of the body for a humorous effect. It can include slapstick, clowning, mime, physical stunts, or making funny faces.

Physical comedy originated as part of the Commedia dell'arte. It is now sometimes incorporated into sitcoms; for example, in the sitcom Three's Company, actor John Ritter frequently performed pratfalls. Cartoons, particularly film shorts, also commonly depict an exaggerated form of physical comedy (incorporating cartoon physics), such as in Tom and Jerry and Wile E. Coyote and the Road Runner.

Melvin Jerome Blanc (born Blank /blæŋk/; May 30, 1908 – July 10, 1989) was an American voice actor and radio personality whose career spanned over 60 years. During the Golden Age of Radio, he provided character voices and vocal sound effects for comedy radio programs, including those of Jack Benny, Abbott and Costello, Burns and Allen, The Great Gildersleeve, Judy Canova and his own short-lived sitcom.

Blanc became known worldwide for his work in the golden age of American animation as the voices of Bugs Bunny, Daffy Duck, Tweety, Sylvester the Cat, Yosemite Sam, Wile E. Coyote and the Road Runner, Speedy Gonzales, Marvin the Martian, Foghorn Leghorn, the Tasmanian Devil, Pepé Le Pew and numerous other characters from the Looney Tunes and Merrie Melodies theatrical cartoons. Blanc also voiced the Looney Tunes characters Porky Pig and Elmer Fudd after replacing their original performers, Joe Dougherty and Arthur Q. Bryan, respectively, although he occasionally voiced Elmer during Bryan's lifetime as well. He later voiced characters for Hanna-Barbera's television cartoons, including: Barney Rubble and Dino on The Flintstones, Mr. Spacely on The Jetsons, Secret Squirrel on The Atom Ant/Secret Squirrel Show, the title character of Speed Buggy, and Captain Caveman on Captain Caveman and the Teen Angels and The Flintstone Kids. He was also the voice of Gideon's hiccups in Pinocchio, his only appearance at Disney. Blanc was also the voice of Woody Woodpecker in the first four animated shorts from 1940 to 1941, his only appearance at Universal Pictures. He also provided the screams for Tom and Jerry in the short films from 1963 to 1967, in just 34 short films directed by Chuck Jones.

The Looney Tunes and Merrie Melodies series of animated shorts released by Warner Bros. feature a range of characters which are listed and briefly detailed here. Major characters from the franchise include Bugs Bunny, Daffy Duck, Elmer Fudd, Foghorn Leghorn, Marvin the Martian, Porky Pig, Speedy Gonzales, Sylvester the Cat, the Tasmanian Devil, Tweety, Wile E. Coyote and the Road Runner, and Yosemite Sam. This list does not include characters from Looney Tunes-related television series, like Tiny Toon Adventures characters, Animaniacs characters, or Duck Dodgers characters, as they have their own list.

Robert Underdunk "Bob" Terwilliger Jr., PhD, better known as Sideshow Bob, is a recurring character and the secondary antagonist in the animated television series The Simpsons. He is voiced by Kelsey Grammer and first appeared in the episode "The Telltale Head". Bob is a self-proclaimed genius who is a graduate of Yale University and a champion of high culture, including the adoption of a transatlantic accent, similar to that of Grammer's portrayal of Dr. Frasier Crane from the sitcoms Cheers and Frasier. He began his career as a sidekick on Krusty the Clown's television show, but after enduring constant abuse, Bob framed his employer for armed robbery in "Krusty Gets Busted", only to be foiled by Bart Simpson, and sent to prison. Bob started seeking revenge against Bart while in prison, and the two became feuding archenemies.

Bob made his second major appearance in season three's "Black Widower"; the writers echoed the premise of Wile E. Coyote chasing the Road Runner by having Bob unexpectedly insert himself into Bart's life, threatening to disrupt and end it through murder. Starting with that appearance and thereafter, Bob has assumed the role on The Simpsons of an evil genius. Episodes in which he is a central character typically involve Sideshow Bob being released from prison and executing an elaborate revenge plan, usually foiled by Bart and Lisa. His plans often involve death and destruction, usually targeted at Bart or, less often, Krusty, though he starts targeting the entire Simpson family in season 17. In season 27, however, during the first segment of "Treehouse of Horror XXVI", entitled "Wanted: Dead, Then Alive", Bob finally gets his wish of killing Bart, commenting that he spent 24 years trying to kill a ten-year-old child; however, he becomes bored with Bart dead, so he brings him back to life so that he can repeatedly kill Bart over and over again.