Whole genome sequencing in the context of "Genetic association"

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⭐ Core Definition: Whole genome sequencing

Whole genome sequencing (WGS), also known as full genome sequencing or just genome sequencing, is the process of determining the entirety of the DNA sequence of an organism's genome at a single time. This entails sequencing all of an organism's chromosomal DNA as well as DNA contained in the mitochondria and, for plants, in the chloroplast.

Whole genome sequencing has largely been used as a research tool, but was being introduced to clinics in 2014. In the future of personalized medicine, whole genome sequence data may be an important tool to guide therapeutic intervention. The tool of gene sequencing at SNP level is also used to pinpoint functional variants from association studies and improve the knowledge available to researchers interested in evolutionary biology, and hence may lay the foundation for predicting disease susceptibility and drug response.

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👉 Whole genome sequencing in the context of Genetic association

Genetic association is when one or more genotypes within a population co-occur with a phenotypic trait more often than would be expected by chance occurrence.

Studies of genetic association aim to test whether single-locus alleles or genotype frequencies or more generally, multilocus haplotype frequencies differ between two groups of individuals (usually diseased subjects and healthy controls). Genetic association studies are based on the principle that genotypes can be compared "directly", i.e. with the sequences of the actual genomes or exomes via whole genome sequencing or whole exome sequencing. Before 2010, DNA sequencing methods were used.

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Whole genome sequencing in the context of Strongylocentrotus purpuratus

Strongylocentrotus purpuratus is a species of sea urchin in the family Strongylocentrotidae, which is commonly known as the purple sea urchin. It lives along the eastern edge of the Pacific Ocean extending from Ensenada, Mexico, to British Columbia, Canada.

After one of its main predators, the sea otter, experienced a population decline, Strongylocentrotus purpuratus became a threat to the health of kelp forests as its own population boomed. The species is also used as a model organism and its genome was the first echinoderm genome to be sequenced.

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Whole genome sequencing in the context of Orange (fruit)

The orange, also called sweet orange to distinguish it from the bitter orange (Citrus × aurantium), is the fruit of a tree in the family Rutaceae. Botanically, this is the hybrid Citrus × sinensis, between the pomelo (Citrus maxima) and the mandarin orange (Citrus reticulata). The chloroplast genome, and therefore the maternal line, is that of pomelo. Hybrids of the sweet orange form later types of mandarin and the grapefruit. The sweet orange has had its full genome sequenced.

The orange originated in a region encompassing Southern China, Northeast India, and Myanmar; the earliest mention of the sweet orange was in Chinese literature in 314 BC. Orange trees are widely grown in tropical and subtropical areas for their sweet fruit. The fruit of the orange tree can be eaten fresh or processed for its juice or fragrant peel. In 2022, 76 million tonnes of oranges were grown worldwide, with Brazil producing 22% of the total, followed by India and China.

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Whole genome sequencing in the context of Genetic history of the Middle East

The genetic history of the Middle East is the subject of research within the fields of human population genomics, archaeogenetics and Middle Eastern studies. Researchers may use Y-DNA, mtDNA, other autosomal DNA, whole genome, or whole exome information to identify the genetic history of ancient and modern populations of Arabia, Egypt, the Levant, Mesopotamia, Persia, Turkey, and other areas.

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Whole genome sequencing in the context of Red junglefowl

The red junglefowl (Gallus gallus), also known as the Indian red junglefowl (and formerly the bankiva or bankiva-fowl), is a species of tropical, galliform bird in the phasianid family, found across much of Southeast and parts of South Asia.

The red junglefowl was the primary species to give rise to today's many breeds of domesticated chicken (G. g. domesticus). Lesser contributions came from the grey junglefowl (G. sonneratii), Sri Lankan junglefowl (G. lafayettii) and the Javanese green junglefowl (G. varius). Whole genome sequencing has revealed that the chicken was first domesticated from red junglefowl ca. 8,000 years ago, with this domestication event involving multiple maternal origins.

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Whole genome sequencing in the context of House mouse

The house mouse (Mus musculus) is a small mammal of the rodent family Muridae, characteristically having a pointed snout, large rounded ears, and a long and almost hairless tail. It is one of the most abundant species of the genus Mus. Although a wild animal, the house mouse has benefited significantly from associating with human habitation to the point that truly wild populations are significantly less common than the synanthropic populations near human activity.

The house mouse has been domesticated as the pet or fancy mouse, and as the laboratory mouse, which is one of the most important model organisms in biology and medicine. The complete mouse reference genome was sequenced in 2002.

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Whole genome sequencing in the context of Adansonia

Adansonia is a genus of medium-to-large deciduous trees known as baobabs (/ˈbbæb/ or /ˈbbæb/). The eight species of Adansonia are native to Africa, Australia, and Madagascar but have also been introduced to other regions of the world, including Barbados, where several of the baobabs there are suspected to have originated from Africa. Other baobabs have been introduced to Asia. A genomic and ecological analysis further suggests that the genus itself originated from Madagascar.

The generic name Adansonia honours Michel Adanson, the French naturalist and explorer who provided the first detailed botanical description and illustrations of Adansonia digitata. The baobab, however, is also known as the "upside down tree," a name attributable to the trees' overall appearance and historical myths. Baobabs are among the longest-lived of vascular plants and have large flowers that are reproductive for a maximum of 15 hours. The flowers open around dusk with sufficiently rapid movement that is detectable by the naked eye. The fruits are large, oval to round and berry-like, and hold kidney-shaped seeds in a dry, pulpy matrix.

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