Western Region, Uganda in the context of "Kasese"

The Allied Democratic Forces (French: Forces démocratiques alliées; abbreviated ADF) is a Ugandan Islamist rebel group based in western Uganda and eastern Democratic Republic of the Congo (DRC). Some refer to the group as IS-DRC as a chapter of IS-CAP, but this terms is broader and tends to include non-ADF rebels. It is considered a terrorist organization by the Ugandan government and the United States. The group is sanctioned by the United States and the United Nations Security Council. Originally based in western Uganda, the ADF has expanded into eastern DRC where nearly all of its fighting has occurred. Most ADF fighters are Ugandan Muslims from the Baganda and Basoga ethnic groups.

Since the late 1990s, the ADF has operated in the Congo's North Kivu province near the border with Uganda. While repeated military offensives against the ADF have severely affected it, the ADF has been able to regenerate because its recruitment and financial networks have remained intact. Some of the attacks it has been blamed for also appear to have been committed by other rebel groups as well as the Armed Forces of the DRC (FARDC).

Kitara (sometimes spelt as Kittara or Kitwara, also known as the Chwezi Empire) was an ancient legendary state that covered significant parts of western Uganda and is regularly mentioned in the oral traditions of the Banyoro, Batooro, and Banyankole.

The Hima or Huma are a pastoralist social class that is native to the grasslands of Western Uganda and Karagwe, Tanzania.

Mbarara City is a city in the Western Region of Uganda and the second largest city in Uganda after Kampala. The city is divided into 6 boroughs of Kakoba Division, Kamukuzi Division, Nyamitanga Division, Biharwe Division, Kakiika Division, Nyakayojo Division. It is the main commercial centre of most of south western districts of Uganda and the site of the district headquarters. In May 2019, the Uganda's cabinet granted Mbarara a city status, which started on 1 July 2020. The name of the municipality came from a colonial mispronunciation of Emburara (Hyperemia rufa), a tall grass that previously covered the whole area.

Hoima is a city in the Western Region of Uganda and is the main municipal, administrative, and commercial center of Hoima District. It is also the location of the palace of the Omukama of Bunyoro.