Villamelendro is a town belonging to the municipality of Villasila de Valdavia, in the region of Vega-Valdavia. It is located in the transition area between the Natural Park Montaña Palentina and the Tierra de Campos in the province Spain of Palencia (Castilla y León), on the upper side of the Triangle formed by Saldaña, Carrión de los Condes and Herrera de Pisuerga and located at the foot of the route Jacobea that linked San Vicente de la Barquera with Carrión de los Condes through the Royal way of La Valdavia.
It is on the right bank of the Valdavia River, joined by the road PP-2454 called camino vecinal (0.8 km) to the kilometre 21.2 of the provincial road P236.