The ventral posterolateral nucleus (VPL) is one of the subdivisions of the ventral posterior nucleus in the ventral nuclear group of the thalamus. It relays sensory information from second-order neurons of the neospinothalamic tract and the medial lemniscus (of the dorsal column-medial lemniscus pathway), which synapse with third-order neurons in the nucleus. These then project to the primary somatosensory cortex in the postcentral gyrus.
There is uncertainty regarding the location of VMpo (posterior part of ventral medial nucleus), as determined by spinothalamic tract (STT) terminations and calcium-binding protein staining, and several authorities do not consider its existence as being proved.