United States Numbered Highway in the context of "U.S. Route 44 in New York"

US Highway 131 (US 131) is a north–south United States Numbered Highway, of which all but 0.64 of its 269.96 miles (1.03 of 434.46 km) are within the state of Michigan. The highway starts in rural Indiana south of the state line as a state road connection to the Indiana Toll Road. As the road crosses into Michigan it becomes a state trunkline highway that connects to the metropolitan areas of Kalamazoo and Grand Rapids before continuing north to its terminus at Petoskey. US 131 runs as a freeway from south of Portage through to Manton in the north. Part of this freeway runs concurrently with Interstate 296 (I-296) as an unsigned designation through Grand Rapids. US 131 forms an important corridor along the western side of the Lower Peninsula of Michigan, running through rural farm and forest lands as well as urban cityscapes. Various names have been applied to the roadway over the years. The oldest, the Mackinaw Trail, originated from an Indian trail in the area while other names honored politicians. An attempt to dedicate the highway to poet James Whitcomb Riley failed to gain official support in Michigan.

The first state highways along the US 131 corridor were designated as early as 1919. When the US Highway System was formed on November 11, 1926, US 131 was created along the route of M-13 in Michigan. Originally ending at Fife Lake on the north end, the highway was extended to Petoskey in the late 1930s. Further changes were made, starting in the 1950s, to convert segments of the road to a full freeway. The state started this conversion simultaneously at two locations: heading north from Three Rivers, and heading both north and south from a point in southern Kent County. A third segment was built south of Cadillac and over subsequent years Michigan filled the gaps in the freeway. Cadillac and Manton were bypassed in the early part of the 21st century, resulting in the current freeway configuration. Another large-scale construction project in 2000 rebuilt an unusual section of the freeway through Grand Rapids known as the S-Curve. Two bridges formerly used by US 131 have been labeled by the Michigan Department of Transportation (MDOT) as historic structures; one of them has been listed on the National Register of Historic Places (NRHP).

U.S. Route 25 or U.S. Highway 25 (US 25) is a north–south United States Numbered Highway that runs for 750 miles (1,210 km) in the Southern and Midwestern U.S. Its southern terminus is in Brunswick, Georgia, from where it proceeds mostly due north, passing through the cities of Augusta, Georgia; Greenville, South Carolina; and Asheville, North Carolina, before dividing into two branches, known as US 25W and US 25E between Newport, Tennessee, and North Corbin, Kentucky. After passing through Richmond and Lexington, Kentucky, it reaches its northern terminus at Ohio state line in Covington, Kentucky. The route is an important crossing of the Appalachian Mountains, and it is covered by three of the corridors of the Appalachian Development Highway System (ADHS). When the highway was originally established in 1926, the route extended from North Augusta, South Carolina, to Port Huron, Michigan. The southern end was extended to its current terminus in 1936, while the northern end was truncated in 1974.

U.S. Route 15 or U.S. Highway 15 (US 15) is a 791.71-mile-long (1,274.13 km) United States Numbered Highway, serving the states of South Carolina, North Carolina, Virginia, Maryland, Pennsylvania, and New York. The route is signed north–south, from US 17 Alternate (US 17 Alt.) in Walterboro, South Carolina, north to Interstate 86 (I-86)/New York State Route 17 (NY 17) in Corning, New York.

US 15 is one of the original U.S. Highways from 1926.

U.S. Route 160 (US 160) is a 1,465-mile-long (2,358 km) east–west United States Numbered Highway in the Midwestern and Western United States. The western terminus of the route is at US 89 five miles (8.0 km) west of Tuba City, Arizona. The eastern terminus is at US 67 and Missouri 158 southwest of Poplar Bluff, Missouri.Its route, if not its number, was made famous in song in 1975, as the road from Wolf Creek Pass to Pagosa Springs, Colorado in C.W. McCall's country music song "Wolf Creek Pass".

U.S. Route 21 or U.S. Highway 21 (US 21) is a north–south United States Numbered Highway, spanning 393 miles (632 km) from Hunting Island State Park, South Carolina, to Wytheville, Virginia. The route traverses three states, South Carolina, North Carolina, and Virginia. It connects southeastern cities, including Columbia, South Carolina, and Charlotte, North Carolina.

US 21 starts at Hunting Island State Park, bypasses Beaufort, South Carolina, and then heads north across the low country, paralleling Interstate 77 (I-77) through urban and rural areas before entering North Carolina. In North Carolina, US 21 frequently merges with and splits from I-77. The route enters Virginia, passing through hilly terrain before ending at the intersection of Interstate 81 (I-81) / U.S. Route 52 (US 52) in Wytheville.

U.S. Route 19E (US 19E) is a divided highway of US 19 in the U.S. states of North Carolina and Tennessee. The United States Numbered Highway, which is complemented by US 19W to the west, travels 75.9 miles (122.1 km) from US 19 and US 19W at Cane River, North Carolina, north to US 11E, US 19, and US 19W in Bluff City, Tennessee. US 19E connects Asheville, North Carolina, and Bristol, Tennessee, with Burnsville, Spruce Pine, and Elk Park in North Carolina and Roan Mountain and Elizabethton in Tennessee. US 19E also has an unsigned concurrency with State Route 37 (SR 37) for its entire course in Tennessee.

U.S. Route 22 (US 22) is a United States Numbered Highway stretching from Cincinnati, Ohio, in the west to Newark, New Jersey, in the east. In New Jersey, the route runs for 60.53 miles (97.41 km) from the Easton–Phillipsburg Toll Bridge over the Delaware River in Phillipsburg, Warren County, to Interstate 78 (I-78), US 1/9, and Route 21 at the Newark Airport Interchange in Newark, Essex County. The road first heads through the Phillipsburg–Alpha area as an arterial road before running concurrent with I-78 through mountainous and agricultural sections of western New Jersey between Alpha and east of Clinton in Hunterdon County. For the remainder of the route, US 22 runs to the south of I-78 through mostly suburban areas as a four- to six-lane arterial road, passing through Hunterdon, Somerset, Union, and Essex counties. Along this portion, it intersects US 202 and US 206 in Somerville, I-287 in Bridgewater Township, and the Garden State Parkway in Union.

What became US 22 in 1926 was first designated as Route 9, a route running from Phillipsburg to Elizabeth, in 1916. In 1927, Route 9 west of Elizabeth became Route 28 while the portion within Elizabeth became Route 27-28 Link. By 1941, US 22 was moved to its current alignment in the Phillipsburg area, following Route 24 and Route 24-28 Link; Route 28 in Phillipsburg became US 22 Alternate (US 22 Alt.; now Route 122). Also, US 22 was moved off Route 28 east of Bridgewater Township to follow Route 28-29 Link and Route 29 to Newark. In 1953, the long concurrencies with the state highways were removed. In the 1960s, I-78 was constructed close to the US 22 corridor throughout New Jersey. US 22 was moved onto the new Interstate between Alpha and Clinton in 1969 with most of the old route becoming Route 173.

U.S. Route 11 (US 11) is a north–south United States Numbered Highway in western Virginia. At 339 miles (546 km), it is the second longest numbered route (after US 58) and longest primarily north–south route in the state. It enters the state from Tennessee as the divided routes US 11E and US 11W at Bristol, roughly follows the West Virginia border through the Blue Ridge Mountains and Shenandoah Valley, and enters the Eastern Panhandle of West Virginia from Frederick County. Most of the route closely parallels I-81. From south to north, US 11 serves the cities and towns of Bristol, Abingdon, Wytheville, Pulaski, Radford, Christiansburg, Roanoke, Lexington, Staunton, Harrisonburg, Strasburg, and Winchester. As one of the original U.S. Highways, it was first designated through Virginia in 1926 and has largely followed the same route since. Prior to the construction of the Interstate Highway System, it was the primary long-distance route for traversing the western part of the state. Much of it roughly follows the Great Wagon Road, a colonial-era road that followed the Appalachian Mountains from Georgia to Pennsylvania.

U.S. Route 15 (US 15) is United States Numbered Highway that runs from Walterboro, South Carolina, north to Painted Post, New York. In Pennsylvania, the highway runs for 194.89 miles (313.65 km), from the Maryland state line just south of Gettysburg, north to the New York state line near Lawrenceville.