Italy has been inhabited by humans since the Paleolithic. During antiquity, there were many peoples in the Italian peninsula, including Etruscans, Latins, Samnites, Umbri, Cisalpine Gauls, Greeks in Magna Graecia and others. Most significantly, Italy was the cradle of the Roman civilization. Rome was founded as a kingdom in 753 BC and became a republic in 509 BC. The Roman Republic then unified Italy forming a confederation of the Italic peoples and rose to dominate Western Europe, Northern Africa, and the Near East. The Roman Empire, established in 27 BC, ruled the Mediterranean region for centuries, contributing to the development of Western culture, philosophy, science and art.
During the early Middle Ages, Italy experienced the succession in power of Ostrogoths, Byzantines, Longobards and the Holy Roman Empire and fragmented into numerous city-states and regional polities, a situation that would remain until the unification of the country. These polities and the maritime republics, in particular Venice and Genoa, rose to prosperity. Eventually, the Italian Renaissance emerged and spread to the rest of Europe, bringing a renewed interest in humanism, science, exploration, and art with the start of the modern era. In the medieval and early modern era, Southern Italy was ruled by the Norman, Swabian and Angevin dynasties and the Aragonese, French and Spanish crowns. Central Italy was largely part of the Papal States.