Interstate 40 (I-40) is an east–west Interstate Highway that has a 284.69-mile (458.16 km) section in the U.S. state of Arkansas, connecting Oklahoma to Tennessee. The route enters Arkansas from the west just north of the Arkansas River near Dora. It travels eastward across the northern portion of the state, connecting the cities of Fort Smith, Clarksville, Russellville, Morrilton, Conway, North Little Rock, Forrest City, and West Memphis. I-40 continues into Tennessee, heading through Memphis. The highway has major junctions with I-540 at Van Buren (the main highway connecting to Fort Smith), I-49 at Alma (the main highway connecting to Fayetteville and Bentonville), I-30 and I-57 in North Little Rock, and I-55 to Blytheville.
For the majority of its routing through Arkansas, I-40 follows the historic alignment of two separate U.S. Highways. From Oklahoma to Little Rock, I-40 generally follows U.S. Highway 64 through the Ozark Mountains. East of Little Rock, the route generally follows the routing of US 70 until the Tennessee state line.