U.S. Route 1 in New York in the context of "Trans-Manhattan Expressway"

Third Avenue is a north-south thoroughfare on the East Side of the New York City borough of Manhattan, as well as in the center portion of the Bronx. Its southern end is at Astor Place and St. Mark's Place. It transitions into Cooper Square, and further south, the Bowery, Chatham Square, and Park Row. The Manhattan side ends at East 128th Street. Third Avenue is two-way from Cooper Square to 24th Street, but carries only northbound (uptown) traffic while in Manhattan above 24th Street; in the Bronx, it is again two-way. However, the Third Avenue Bridge carries vehicular traffic in the opposite direction, allowing only southbound vehicular traffic, rendering the avenue essentially non-continuous to motor vehicles between the boroughs.

The street leaves Manhattan and continues into the Bronx across the Harlem River over the Third Avenue Bridge north of East 129th Street to East Fordham Road at Fordham Center, where it intersects with U.S. 1. It is one of the four streets that form The Hub, a site of both maximum traffic and architectural density in the South Bronx.

Interstate 95 (I-95) is part of the Interstate Highway System and runs from Miami, Florida, to the Canada–United States border near Houlton, Maine. In the US state of New York, I-95 extends 23.50 miles (37.82 km) from the George Washington Bridge in New York City to the Connecticut state line at Port Chester. The George Washington Bridge carries I-95 across the Hudson River from New Jersey into New York City. There, I-95 runs across Upper Manhattan on the Trans-Manhattan Expressway for 0.81 miles (1.30 km) through Washington Heights. It continues east across the Harlem River on the Alexander Hamilton Bridge and onto the Cross Bronx Expressway. In the Bronx, I-95 leaves the Cross Bronx at the Bruckner Interchange, joining the Bruckner Expressway to its end. North of the interchange with Pelham Parkway, it continues northeast via the New England Thruway (part of the New York State Thruway system) into Westchester County and to the Connecticut state line, where I-95 continues on the Connecticut Turnpike.

The Trans-Manhattan Expressway also carries US Route 1. An average of about 280,000 vehicles traverse the expressway each day. Completed in 1960, the expressway sits below ground level in an open cut; the George Washington Bridge Bus Station and the highrise Bridge Apartments are built over the expressway, creating intermittent tunnels. It is maintained by the Port Authority of New York and New Jersey (PANYNJ). Although the highway geographically runs east–west, it carries the north–south routings of I-95 and US 1. The westbound lanes carry the southbound designations of both routes, while the eastbound lanes carry the northbound designations.

The Cross Bronx Expressway is a major freeway in the New York City borough of the Bronx. It is mainly designated as part of Interstate 95 (I-95), but also includes portions of I-295 and U.S. Route 1 (US 1). The Cross Bronx begins at the eastern approach to the Alexander Hamilton Bridge over the Harlem River. While I-95 leaves at the Bruckner Interchange in Throgs Neck, following the Bruckner Expressway and New England Thruway to Connecticut, the Cross Bronx Expressway continues east, carrying I-295 to the merge with the Throgs Neck Expressway near the Throgs Neck Bridge. Though the road goes primarily northwest-to-southeast, the nominal directions of all route numbers west of the Bruckner Interchange are aligned with the northbound route number going southeast, and the southbound route number going northwest.

The Cross Bronx Expressway was conceived by Robert Moses and built between 1948 and 1972. It was the first highway built through a crowded urban environment in the United States; the most expensive mile of road ever built to that point is part of the Cross Bronx, costing $40 million (equivalent to $469,515,528 in 2024). At one point during construction, Moses' crews had to support the Grand Concourse (a major surface thoroughfare), a subway line and several elevated train lines while the expressway was laboriously pushed through. The highway experiences severe traffic problems, and its construction has been blamed for negatively affecting a number of low-income neighborhoods in the South Bronx. Most Bronxites consider the Cross Bronx Expressway the defining border between the North and the South Bronx.

Baychester is a neighborhood geographically located in the northeast part of the Bronx, New York City. Its boundaries are East 222nd Street to the northeast, the New England Thruway (Interstate 95) to the east, Gun Hill Road to the southwest, and Boston Road to the northwest. Eastchester Road is the primary thoroughfare through Baychester.

The neighborhood is part of Bronx Community Board 12. Many homes are located on streets in the 201s and advancing to the 220s. While 10469 is the primary ZIP Code of Baychester, it also covers the adjacent neighborhood of Pelham Gardens, Bronx. The area is patrolled by the 47th Precinct of the New York City Police Department.

Eastchester is a working-class neighborhood in the northeast Bronx in New York City. Its boundaries, starting from the north and moving clockwise are the Bronx-Westchester County border to the north, the New England Thruway to the east, Baychester Avenue to the south, and the intersection of 233rd Street and Baychester Avenue to the west. Boston Road is the primary thoroughfare through Eastchester and Dyre Avenue is the main commercial street. Eastchester includes the sub-neighborhood of Edenwald.

Eastchester is part of Bronx Community Board 12, and its ZIP Codes include 10466 and 10475. The area is patrolled by the 47th Precinct of the New York City Police Department.