The mesosphere (/ˈmɛsəsfɪər, ˈmɛz-, ˈmiːsə-, -zə-/; from Ancient Greek μέσος (mésos) 'middle' and -sphere) is the third layer of the atmosphere, directly above the stratosphere and directly below the thermosphere. In the mesosphere, temperature decreases as altitude increases. This characteristic is used to define limits: it begins at the top of the stratosphere (sometimes called the stratopause), and ends at the mesopause, which is the coldest part of Earth's atmosphere, with temperatures below −143 °C (−225 °F; 130 K). The exact upper and lower boundaries of the mesosphere vary with latitude and with season (higher in winter and at the tropics, lower in summer and at the poles), but the lower boundary is usually located at altitudes from 47 to 51 km (29 to 32 mi; 154,000 to 167,000 ft) above sea level, and the upper boundary (the mesopause) is usually from 85 to 100 km (53 to 62 mi; 279,000 to 328,000 ft).
The stratosphere and mesosphere are sometimes collectively referred to as the "middle atmosphere", which spans altitudes approximately between 12 and 80 km (7.5 and 49.7 mi) above Earth's surface. The mesopause, at an altitude of 80–90 km (50–56 mi), separates the mesosphere from the thermosphere—the second-outermost layer of Earth's atmosphere. On Earth, the mesopause nearly co-incides with the turbopause, below which different chemical species are well-mixed due to turbulent eddies. Above this level the atmosphere becomes non-uniform because the scale heights of different chemical species differ according to their molecular masses.