Therapsid in the context of "William Diller Matthew"

A tetrapod (/ˈtɛtrəˌpɒd/; from Ancient Greek τετρα- (tetra-) 'four' and πούς (poús) 'foot') is any vertebrate animal of the clade Tetrapoda (/tɛˈtræpədə/). Tetrapods include all extant and extinct amphibians and amniotes, with the latter in turn evolving into two major clades, the sauropsids (reptiles, including dinosaurs and therefore birds) and synapsids (extinct "pelycosaurs", therapsids and all extant mammals, including humans). Hox gene mutations have resulted in some tetrapods becoming limbless (snakes, legless lizards, and caecilians) or two-limbed (cetaceans, sirenians, some lizards, kiwis, and the extinct moa and elephant birds). Nevertheless, they still qualify as tetrapods through their ancestry, and some retain a pair of vestigial spurs that are remnants of the hindlimbs.

Tetrapods evolved from a group of semiaquatic animals within the tetrapodomorphs which, in turn, evolved from ancient lobe-finned fish (sarcopterygians) around 390 million years ago in the Middle Devonian period. Early tetrapodomorphs were transitional between lobe-finned fishes and true four-limbed tetrapods, though most still fit the body plan expected of other lobe-finned fishes. The oldest fossils of four-limbed vertebrates (tetrapods in the broad sense of the word) are trackways from the Middle Devonian, and body fossils became common near the end of the Late Devonian, around 370–360 million years ago. These Devonian species all belonged to the tetrapod stem group, meaning that they did not belong to any modern tetrapod group.

Dicynodontia is an extinct clade of anomodonts, an extinct type of non-mammalian therapsid. Dicynodonts were herbivores that typically bore a pair of tusks, hence their name, which means 'two dog tooth'. Members of the group possessed a horny, typically toothless beak, unique amongst all synapsids. Dicynodonts first appeared in Southern Pangaea during the mid-Permian, ca. 270–260 million years ago, and became globally distributed and the dominant herbivorous animals in the Late Permian, ca. 260–252 Mya. They were devastated by the end-Permian mass extinction that wiped out most other therapsids ca. 252 Mya. They rebounded at beginning of the following Triassic, but subsequently declined and died out towards the end of that period. They were the most successful and diverse of the non-mammalian therapsids, with over 80-90 genera known, varying from rat-sized burrowers to elephant-sized browsers.

Cynodontia (from Ancient Greek κύων (kúōn) 'dog' and ὀδούς (odoús) 'tooth') is a clade of eutheriodont therapsids that first appeared in the Late Permian (approximately 260 mya), and extensively diversified after the Permian–Triassic extinction event. Mammals are cynodonts, as are their extinct ancestors and close relatives (Mammaliaformes), having evolved from advanced probainognathian cynodonts during the Late Triassic.

Non-mammalian cynodonts occupied a variety of ecological niches, both as carnivores and as herbivores. Following the emergence of mammals, most other cynodont lines went extinct, with the last known non-mammaliaform cynodont group, the Tritylodontidae, having its youngest records in the Early Cretaceous.

Synapsida is a diverse group of tetrapod vertebrates that includes all mammals and their extinct relatives. It is one of the two major clades of the group Amniota, the other being the more diverse group Sauropsida (which includes all extant reptiles and, therefore, birds). Unlike other amniotes, synapsids have a single temporal fenestra, an opening low in the skull roof behind each eye socket, leaving a bony arch beneath each; this accounts for the name "synapsid". The distinctive temporal fenestra developed about 318 million years ago during the Late Carboniferous period, when synapsids and sauropsids diverged, but was subsequently merged with the orbit in early mammals.

The basal amniotes (reptiliomorphs) from which synapsids evolved were historically simply called "reptiles". Therefore, stem group synapsids were then described as mammal-like reptiles in classical systematics, and non-therapsid synapsids were also referred to as pelycosaurs or pelycosaur-grade synapsids. These paraphyletic terms have now fallen out of favor and are only used informally (if at all) in modern literature, as it is now known that all extant reptiles are more closely related to each other and birds than to synapsids, so the word "reptile" has been re-defined to mean only members of Sauropsida or even just an under-clade thereof. In a cladistic sense, synapsids are in fact a monophyletic sister taxon of sauropsids, rather than a part of the sauropsid lineage. Therefore, calling synapsids "mammal-like reptiles" is incorrect under the new definition of "reptile", so they are now referred to as stem mammals, proto-mammals, paramammals or pan-mammals. Most lineages of pelycosaur-grade synapsids were replaced by the more advanced therapsids, which evolved from sphenacodontoid pelycosaurs, at the end of the Early Permian during the so-called Olson's Extinction.

The Guadalupian is the second and middle series/epoch of the Permian. The Guadalupian was preceded by the Cisuralian and followed by the Lopingian. It is named after the Guadalupe Mountains of New Mexico and Texas, and dates between 274.4 ± 0.4 – 259.51 ± 0.21 Mya. The series saw the rise of the therapsids, a minor extinction event called Olson's Extinction and a significant mass extinction called the end-Capitanian extinction event. The Guadalupian is also known as the Middle Permian.

Pareiasaurs (meaning "cheek lizards") are an extinct clade of large, herbivorous parareptiles. Members of the group were armoured with osteoderms which covered large areas of the body. They first appeared in southern Pangea during the Middle Permian, before becoming globally distributed during the Late Permian. Pareiasaurs were the largest reptiles of the Permian, some reaching sizes over 1 tonne (2,200 lb), equivalent to the largest contemporary therapsids. Pareiasaurs became extinct in the end-Permian mass extinction event.