Sankhuwasabha District (Nepali: सङ्खुवासभा जिल्ला ) is one of 14 districts of Koshi Province of eastern Nepal. The district's area is 3,480 km with a population of 159,203 in 2001 and 158,742 in 2011. The administrative center is Khandbari.
Bordering districts are Bhojpur, Tehrathum, Dhankuta, Solukhumbu and Taplejung in Koshi Province. Tingri County of Shigatse Prefecture in the Tibet Autonomous Region of China borders to the north.