Mess Creek, formerly known as Mestua, is a tributary of the Stikine River in northwestern British Columbia, Canada. It flows north and northwest for about 110 km (68 mi), through a lake and a gorge to join the Stikine River, which in turn flows southwest across the Canada–United States border into Alaska where it empties into various straits of the Inside Passage. The northern half of Mess Creek forms a western boundary of Mount Edziza Provincial Park which lies within the traditional territory of the Tahltan people.
Mess Creek's watershed covers 2,330 km (900 sq mi) and its estimated mean annual discharge is 59.3 m/s (2,090 cu ft/s). The mouth of Mess Creek is located about 3 km (1.9 mi) southwest of Telegraph Creek, about 73 km (45 mi) west of Iskut and about 94 km (58 mi) southwest of Dease Lake in Cassiar Land District. Mess Creek's watershed's land cover is classified as 38.7% conifer forest, 25% barren, 15.9% shrubland, 10% snow/glacier, 8.3% herbaceous and small amounts of other cover.