Sulfonamide (medicine) in the context of "Sulfanilamide"

An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of such infections. They may either kill or inhibit the growth of bacteria. A limited number of antibiotics also possess antiprotozoal activity. Antibiotics are not effective against viruses such as the ones which cause the common cold or influenza. Drugs which inhibit growth of viruses are termed antiviral drugs or antivirals. Antibiotics are also not effective against fungi. Drugs which inhibit growth of fungi are called antifungal drugs.

Sometimes, the term antibiotic—literally "opposing life", from the Greek roots ἀντι anti, "against" and βίος bios, "life"—is broadly used to refer to any substance used against microbes, but in the usual medical usage, antibiotics (such as penicillin) are those produced naturally (by one microorganism fighting another), whereas non-antibiotic antibacterials (such as sulfonamides and antiseptics) are fully synthetic. However, both classes have the same effect of killing or preventing the growth of microorganisms, and both are included in antimicrobial chemotherapy. "Antibacterials" include bactericides, bacteriostatics, antibacterial soaps, and chemical disinfectants, whereas antibiotics are an important class of antibacterials used more specifically in medicine and sometimes in livestock feed.

An antimicrobial is an agent that kills microorganisms (microbicide) or stops their growth (bacteriostatic agent). Antimicrobial medicines can be grouped according to the microorganisms they are used to treat. For example, antibiotics are used against bacteria, and antifungals are used against fungi. They can also be classified according to their function. Antimicrobial medicines to treat infection are known as antimicrobial chemotherapy, while antimicrobial drugs are used to prevent infection, which known as antimicrobial prophylaxis.

The main classes of antimicrobial agents are disinfectants (non-selective agents, such as bleach), which kill a wide range of microbes on surfaces to prevent the spread of illness, antiseptics which are applied to living tissue and help reduce infection during surgery, and antibiotics which destroy microorganisms within the body. The term antibiotic originally described only those formulations derived from living microorganisms but is now also applied to synthetic agents, such as sulfonamides or fluoroquinolones. Though the term used to be restricted to antibacterials, its context has broadened to include all antimicrobials. In response, further advancements in antimicrobial technologies have resulted in solutions that can go beyond simply inhibiting microbial growth. Instead, certain types of porous media have been developed to kill microbes on contact. The misuse and overuse of antimicrobials in humans, animals and plants are the main drivers in the development of drug-resistant pathogens. It is estimated that bacterial antimicrobial resistance (AMR) was directly responsible for 1.27 million global deaths in 2019 and contributed to 4.95 million deaths.

Elixir sulfanilamide was an improperly prepared sulfonamide antibiotic that caused mass poisoning in the United States in 1937. It is believed to have killed 107 people. The public outcry caused by this incident and other similar disasters led to the passing of the 1938 Federal Food, Drug, and Cosmetic Act, which significantly increased the Food and Drug Administration's powers to regulate drugs.

Ravensbrück (German: [ˌʁaːvn̩sˈbʁʏk]) was a Nazi Germany concentration camp exclusively for women from 1939 to 1945, located in northern Germany, 90 km (56 mi) north of Berlin at a site near the village of Ravensbrück (part of Fürstenberg/Havel). The camp memorial's estimated figure of 132,000 women who were in the camp during the war includes about 48,500 from Poland, 28,000 from the Soviet Union, almost 24,000 from Germany and Austria, nearly 8,000 from France, almost 2,000 from Belgium, and thousands from other countries including a few from the United Kingdom and the United States. More than 20,000 (15 percent) of the total were Jewish. More than 80 percent were political prisoners. Many prisoners were employed as slave laborers by Siemens & Halske. From 1942 to 1945, the Nazis undertook medical experiments on Ravensbrück prisoners to test the effectiveness of sulfonamides.

In the spring of 1941, the SS established a small adjacent camp for male inmates, who built and managed the camp's gas chambers in January 1945. Of the female prisoners who passed through the Ravensbrück camp, about 50,000 perished. No precise accounting for the number of prisoners murdered in the gas-chamber at Ravensbrück can be given, but a compilation of witness accounts suggests that the number was over 5,000 and the true figure may have been much higher.