Spelthorne was a hundred (dated subdivision) of the historic county of Middlesex, England. It contained these parishes and settlements:
- Ashford
- East Bedfont
- The hamlet of Hatton
- Feltham
- Hampton
- The settlement of Hampton Hill developed in the 19th century
- Hampton Wick
- Hanworth
- Laleham
- Littleton since the 1970s contiguous with Shepperton
- The chapelry of Astleham/Aslam. In the 1930s replaced with the Queen Mary Reservoir.
- Shepperton
- Staines
- Stanwell
- The hamlet of Stanwell Moor, since the 20th century a village without a church
- Sunbury
- The hamlet of Upper Halliford, today a village, joined postally with Shepperton
- The hamlet of Charlton, joined postally with Shepperton
- Teddington
- Part of the neighbourhood of Fulwell, once a single-ownership estate, by consensus spreading south to around to its railway station
The present-day district of Spelthorne in Surrey amounts to about 59% of the hundred. The eastern parts since 1965 form parts of the London boroughs of Hounslow and Richmond upon Thames.