During the Spanish colonization of the Americas, the Spanish Main comprised the parts of the Spanish Empire that were on the mainland of the Americas and had coastlines on the Caribbean Sea or Gulf of Mexico. The term was used by English speakers to distinguish those regions from the numerous islands Spain controlled in the Caribbean, which were known as the Spanish West Indies.
Antón de Alaminos (c. 1482 - ?) was a Spanish navigator and explorer in the New World. He was considered the most experienced and knowledgeable marine pilot serving in the Spanish Main during the first quarter of the sixteenth century.
Antón de Alaminos was born in Palos de la Frontera around 1482 and joined Christopher Columbus on his fourth voyage to the Americas in 1502.
Charles V (24 February 1500 – 21 September 1558) was Holy Roman Emperor and Archduke of Austria from 1519 to 1556, King of Spain (as Charles I) from 1516 to 1556, King of Sicily and Naples from 1516 to 1554, and also Lord of the Netherlands and titular Duke of Burgundy (as Charles II) from 1506 to 1555. He was heir to and then head of the rising House of Habsburg. His dominions in Europe included the Holy Roman Empire, extending from Germany to northern Italy with rule over the Austrian hereditary lands and Burgundian Low Countries, and Spain with its possessions of the southern Italian kingdoms of Sicily, Naples, and Sardinia. In the Americas, he oversaw the continuation of Spanish colonization and a short-lived German colonization. The personal union of the European and American territories he ruled was the first collection of realms labelled "the empire on which the sun never sets".
Charles was born in Flanders to Habsburg Archduke Philip the Handsome, son of Maximilian I, Holy Roman Emperor and Mary of Burgundy, and Joanna of Castile, younger child of Isabella I of Castile and Ferdinand II of Aragon, the Catholic Monarchs of Spain. Heir of his grandparents, Charles inherited his family dominions at a young age. After his father's death in 1506, he inherited the Habsburg Netherlands in the Low Countries. In 1516 he became King of Spain as co-monarch of Castile and Aragon with his mother. Spain's possessions included the Castilian colonies of the West Indies and the Spanish Main, as well as Naples, Sicily, and Sardinia. At the death of his grandfather Maximilian in 1519, he inherited the Austrian hereditary lands and was elected as Holy Roman Emperor. He adopted the Imperial name of Charles V as his main title, and styled himself as a new Charlemagne.
Sir Francis Drake (c. 1540 – 28 January 1596) was an English explorer and privateer best known for making the second circumnavigation of the world in a single expedition between 1577 and 1580 (being the first English expedition to accomplish this). He is also known for participating in the early English slaving voyages of his cousin, John Hawkins, and John Lovell. Having started as a simple seaman, in 1588 he was part of the fight against the Spanish Armada as a vice admiral.
At an early age, Drake was placed into the household of a relative, William Hawkins, a prominent sea captain in Plymouth. In 1572, he set sail on his first independent mission, privateering along the Spanish Main. Drake's circumnavigation began on 15 December 1577. He crossed the Pacific Ocean, until then an area of exclusive Spanish interest, and laid claim to New Albion, plundering coastal towns and ships for treasure and supplies as he went. He arrived back in England on 26 September 1580. Elizabeth I awarded Drake a knighthood in 1581 which he received aboard his galleon the Golden Hind.
The Real Audiencia of Santo Domingo (transl. "Royal Audience of Santo Domingo") was the first court of the Spanish crown in America. It was created by Ferdinand V of Castile in his decree of 1511, but due to disagreements between the governor of Hispaniola, Diego Colon and the Crown, it was not implemented until it was reestablished by Charles V in his decree of September 14, 1526. This audiencia would become part of the Viceroyalty of New Spain upon the creation of the latter two decades later. Nevertheless, the audiencia president was at the same time governor and captain general of the Captaincy General of Santo Domingo, which granted him broad administrative powers and autonomy over the Spanish possessions of the Caribbean and most of its mainland coasts. This combined with the judicial oversight that the audiencia judges had over the region meant that the Santo Domingo Audiencia was the principal political entity of this region during the colonial period.
Christopher Newport (1561–1617) was an English seaman and privateer. During the war with Spain Newport was one of the most successful 'Elizabethan Sea Dogs' to venture to the Spanish Main, making large profits.
Newport is best known as the captain of the Susan Constant, the largest of three ships which carried settlers for the Virginia Company in 1607 on the way to found the settlement at Jamestown in the Virginia Colony, which became the first permanent English settlement in North America. He was also in overall command of the other two ships on that initial voyage, in order of their size, the Godspeed and the Discovery.