The Soyuz TMA-M was a spacecraft developed by Energia and operated by Roscosmos for human spaceflight. Introduced in 2010, it was a revision of the Soyuz spacecraft with upgrades over its predecessor, the Soyuz TMA. It flew a total of 23 missions from 2010-16, all carrying astronauts to the International Space Station (ISS). It was replaced by the Soyuz MS.