Six Nations of the Grand River in the context of "Mississaugas of the New Credit First Nation"

The Seneca Nation of Indians is a federally recognized Seneca tribe based in western New York. They are one of three federally recognized Seneca entities in the United States, the others being the Tonawanda Band of Seneca (also in western New York) and the Seneca-Cayuga Nation of Oklahoma. Some Seneca also live with other Iroquois peoples on the Six Nations of the Grand River in Ontario.

The Seneca Nation has three reservations, two of which are occupied: Cattaraugus Reservation, Allegany Indian Reservation, and the mostly unpopulated Oil Springs Reservation. It has two alternating capitals on the two occupied reservations: Irving at Cattaraugus Reservation, and Jimerson Town near Salamanca on the Allegany Reservation. The tribe also claims sovereignty over a portion of the Canawaugus settlement as of 2022, which is not federally recognized. An additional territory de facto governed by the nation, the Cornplanter Tract in Pennsylvania, officially expired in 1957 and was submerged by the construction of the Allegheny Reservoir in 1965.

The Assateague (meaning: "swifly moving water") were an Algonquian people speaking the Nanticoke language who historically lived on the Atlantic coast side of the Delmarva Peninsula (known during the colonial period as the Eastern Shores of Maryland and Virginia, and the Lower Counties of Pennsylvania).

While there are living people who may have distant heritage from this tribe, including some citizens of the Six Nations of the Grand River, the tribe itself no longer exists as a culturally intact tribal community.

The Cayuga (Cayuga: Gayogo̱hó꞉nǫʼ, "People of the Great Swamp") are one of the five original constituents of the Haudenosaunee (Iroquois), a confederacy of Native Americans in New York. The Cayuga homeland lies in the Finger Lakes region along Cayuga Lake, between their league neighbors, the Onondaga to the east and the Seneca to the west. Today, Cayuga people belong to the Six Nations of the Grand River First Nation in Ontario, and the federally recognized Cayuga Nation of New York and the Seneca-Cayuga Nation of Oklahoma.

The Oneida people (/oʊˈnaɪdə/ oh-NY-də; autonym: Onʌyoteˀa·ká·, Onyotaʼa:ka, the People of the Standing Stone) are a Native American tribe and First Nations band. They are one of the five founding nations of the Iroquois Confederacy in the area of upstate New York, particularly near the Great Lakes and around Oneida Lake and Oneida County.

The Oneida have two federally recognized tribes in the United States: the Oneida Indian Nation in New York, and the Oneida Nation in and around Green Bay, Wisconsin. In Canada the two Oneida First Nations are both located in Ontario: the Six Nations of the Grand River, and the Oneida Nation of the Thames in Southwold.

The Grand River, formerly known as the River Ouse, is a large river in Ontario, Canada. It lies along the western fringe of the Greater Golden Horseshoe region of Ontario which overlaps the eastern portion of southwestern Ontario, sometimes referred to as Midwestern Ontario, along the length of this river. From its source near Wareham, Ontario, it flows south through Grand Valley, Fergus, Elora, Waterloo, Kitchener, Cambridge, Paris, Brantford, Ohsweken, Six Nations of the Grand River, Caledonia, and Cayuga before emptying into the north shore of Lake Erie south of Dunnville at Port Maitland. One of the scenic and spectacular features of the river is the falls and Gorge at Elora.

The Grand River is the largest river that is entirely within southern Ontario's boundaries. The river owes its size to the unusual fact that its source is relatively close to the Georgian Bay of Lake Huron, yet it flows southwards to Lake Erie, rather than westward to the closer Lake Huron or northward to Georgian Bay (most southern Ontario rivers flow into the nearest Great Lake, which is why most of them are small), thus giving it more distance to take in more water from tributaries.

Brantford is a city in Ontario, Canada, founded on the Grand River in Southwestern Ontario. It is surrounded by Brant County but is politically separate with a municipal government of its own that is fully independent of the county's municipal government.

Brantford is situated on the Haldimand Tract, and is named after Joseph Brant, a Mohawk leader, soldier, farmer and slave owner. Brant was an important Loyalist leader during the American Revolutionary War and later, after the Haudenosaunee moved to the Brantford area in Upper Canada. Many of his descendants and other First Nations people live on the nearby Six Nations of the Grand River reserve south of Brantford; it is the most populous reserve in Canada.