Simone Martini in the context of "Fitzwilliam Museum"

Siena (/siˈɛnə/ see-EN-ə, Italian: [ˈsjɛːna, ˈsjeːna] ; traditionally spelled Sienna in English; Latin: Saena Iulia) is a city in Tuscany, in Central Italy, and the capital of the province of Siena. With a population of 52,991, it is the 12th-largest city in the region as of 2025.

The city is historically linked to commercial and banking activities, having been a major banking centre until the 13th and 14th centuries. Siena is also home to the oldest bank in the world, the Monte dei Paschi, which has been operating continuously since 1472 (553 years ago) (1472). Several significant Mediaeval and Renaissance painters were born and worked in Siena, among them Duccio di Buoninsegna, Ambrogio Lorenzetti, Simone Martini and Sassetta, and influenced the course of Italian and European art. The University of Siena, originally called Studium Senese, was founded in 1240, making it one of the oldest universities in continuous operation in the world.

The Annunciation has been one of the most frequent subjects of Christian art. Depictions of the Annunciation go back to early Christianity, with the Priscilla catacomb in Rome including the oldest known fresco of the Annunciation, dating to the 4th century.

Scenes depicting the Annunciation represent the perpetual virginity of Mary via the announcement by the angel Gabriel that Mary would conceive a child to be born the son of God.

The Basilica of Saint Francis of Assisi (Italian: Basilica di San Francesco d'Assisi; Latin: Basilica Sancti Francisci Assisiensis) is the mother church of the Roman Catholic Order of Friars Minor Conventual in Assisi, a town in the Umbria region in central Italy, where Saint Francis was born and died. It is a papal minor basilica and one of the most important places of Christian pilgrimage in Italy. With its accompanying friary, Sacro Convento, the basilica is a distinctive landmark to those approaching Assisi. It has been a UNESCO World Heritage Site since 2000.

The basilica, which was begun in 1228, is built into the side of a hill and comprises two churches (known as the Upper Church and the Lower Church) and a crypt, where the remains of the saint are interred. The interior of the Upper Church is an important early example of the Gothic style in Italy. The Upper and Lower Churches are decorated with frescoes by numerous late medieval painters from the Roman and Tuscan schools, and include works by Cimabue, Giotto, Simone Martini, Pietro Lorenzetti, and possibly Pietro Cavallini. The range and quality of the works give the basilica a unique importance in demonstrating the outstanding development of Italian art of this period, especially if compared with the rest of Christian Europe.

The Sienese school of painting flourished in Siena, Italy, between the 13th and 15th centuries. Its most important artists include Duccio, whose work shows Byzantine influence, his pupil Simone Martini, the brothers Pietro and Ambrogio Lorenzetti and Domenico and Taddeo di Bartolo, Sassetta, and Matteo di Giovanni.