Siena (/siˈɛnə/ see-EN-ə, Italian: [ˈsjɛːna, ˈsjeːna] ; traditionally spelled Sienna in English; Latin: Saena Iulia) is a city in Tuscany, in Central Italy, and the capital of the province of Siena. With a population of 52,991, it is the 12th-largest city in the region as of 2025.
The city is historically linked to commercial and banking activities, having been a major banking centre until the 13th and 14th centuries. Siena is also home to the oldest bank in the world, the Monte dei Paschi, which has been operating continuously since 1472. Several significant Mediaeval and Renaissance painters were born and worked in Siena, among them Duccio di Buoninsegna, Ambrogio Lorenzetti, Simone Martini and Sassetta, and influenced the course of Italian and European art. The University of Siena, originally called Studium Senese, was founded in 1240, making it one of the oldest universities in continuous operation in the world.