Severe acute respiratory syndrome coronavirus 2 in the context of "Bat virome"

Wuhan is the capital of Hubei, China. With a population of over eleven million, it is the most populous city in Hubei and the seventh-most-populous city in China. It is also one of China's nine national central cities.

Wuhan historically served as a busy city port for commerce and trading with some crucial influences on Chinese history. The name "Wuhan" came from the city's historical origin from the conglomeration of Wuchang, Hankou, and Hanyang, which are collectively known as the "Three Towns of Wuhan" (武汉三镇). Wuhan lies in the eastern Jianghan Plain, at the confluence of the Yangtze river and its largest tributary, the Han River, and is known as "Nine Provinces' Thoroughfare" (九省通衢). Wuhan was the site of the 1911 Wuchang Uprising against the Qing dynasty which ended 2,000 years of dynastic rule. Wuhan was briefly a capital of China twice, in 1927 under a left wing Kuomintang (KMT) government, and in 1937 as a provisional wartime capital during World War II. In 1938, during the Second Sino-Japanese War, the city was the site of the Battle of Wuhan. On December 31, 2019, SARS-CoV-2, a novel coronavirus that later caused the COVID-19 pandemic, was first discovered in Wuhan and the city was the location of the first lockdown of the pandemic in January 2020.

The COVID-19 pandemic in China is part of the worldwide pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). China was the first country to experience an outbreak of the disease, the first to impose drastic measures in response (including lockdowns and face mask mandates), and one of the first countries to bring the outbreak under control.

The first wave of the disease manifested as the 2019–2020 COVID-19 outbreak in mainland China, beginning with a cluster of mysterious pneumonia cases, mostly related to the Huanan Seafood Market, in Wuhan, the capital of Hubei province. It was first reported to the local government on 27 December 2019, and published on 31 December. On 8 January 2020, a new coronavirus (SARS-CoV-2) was identified as the cause of the pneumonia by Chinese scientists. By 29 January, the virus was found to have spread to all provinces of mainland China. The virus was first confirmed to have spread to Hong Kong on 23 January 2020, thus originating the COVID-19 pandemic in Hong Kong. Confirmed cases were generally transferred to Princess Margaret Hospital's Infectious Disease Centre for isolation and centralized treatment. On 5 February, after a five-day strike by front-line medical workers, the Hong Kong government closed all but three border control points – Hong Kong International Airport, Shenzhen Bay Control Point, and Hong Kong–Zhuhai–Macau Bridge Control Point remaining open. The first case of the disease in Macau was confirmed on 22 January 2020, originating the COVID-19 pandemic in Macau. The city saw nine more cases by 4 February, but no more cases until 15 March, when imported cases began to appear. Until 26 April 2021, the city had 49 cumulative confirmed cases of COVID-19, all of those having recovered, and no deaths from the disease. Stringent government measures have included the 15-day closure of all 81 casinos in the territory in February; in addition, effective 25 March, the territory disallowed connecting flights at its airport as well as entry by all non-residents (with the exception of residents of mainland China, Hong Kong, and Taiwan), and from 6 April, the Hong Kong–Zhuhai–Macau Bridge was closed to public transport and most other traffic.

Severe acute respiratory syndrome–related coronavirus (SARSr-CoV or SARS-CoV, Betacoronavirus pandemicum) is a species of virus consisting of many known strains. Two strains of the virus have caused outbreaks of severe respiratory diseases in humans: severe acute respiratory syndrome coronavirus 1 (SARS-CoV or SARS-CoV-1), the cause of the 2002–2004 outbreak of severe acute respiratory syndrome (SARS), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the pandemic of COVID-19. There are hundreds of other strains of SARSr-CoV, which are only known to infect non-human mammal species: bats are a major reservoir of many strains of SARSr-CoV; several strains have been identified in Himalayan palm civets, which were likely ancestors of SARS-CoV-1.

These enveloped, positive-sense single-stranded RNA viruses enter host cells by binding to the angiotensin-converting enzyme 2 (ACE2) receptor. The SARSr-CoV species is a member of the genus Betacoronavirus and the only species of the subgenus Sarbecovirus (SARS Betacoronavirus).

The Coalition for Epidemic Preparedness Innovations (CEPI) is a foundation that takes donations from public, private, philanthropic, and civil society organisations, to finance independent research projects to develop vaccines against emerging infectious diseases (EID).

CEPI is focused on the World Health Organization's (WHO) "blueprint priority diseases", which include: the Middle East respiratory syndrome-related coronavirus (MERS-CoV), the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the Nipah virus, the Lassa fever virus, and the Rift Valley fever virus, as well as the Chikungunya virus and the hypothetical, unknown pathogen "Disease X". CEPI investment also requires "equitable access" to the vaccines during outbreaks, although subsequent CEPI policy changes may have compromised this criterion. In 2022, CEPI adopted a vision for the world to be able to respond to a pandemic threat with a new vaccine within 100 days.

An infrared sauna uses infrared heaters to emit infrared light experienced as radiant heat which is absorbed by the surface of the skin. Infrared saunas are popular in alternative therapies, where they are claimed to help with a number of medical issues including autism, cancer, and COVID-19, but these claims are entirely pseudoscientific. Traditional saunas differ from infrared saunas in that they heat the body primarily by conduction and convection from the heated air and by radiation of the heated surfaces in the sauna room whereas infrared saunas primarily use just radiation.

Infrared saunas are also used in Infrared Therapy and Waon Therapy; while there is a small amount of preliminary evidence that these therapies correlate with a number of benefits, including reduced blood pressure, increased heart rate and increased left ventricular function, there are several problems with linking this evidence to alleged health benefits.

The COVID-19 pandemic in Italy was part of the COVID-19 pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

The virus was first confirmed to have spread to Italy on 31 January 2020, when two Chinese tourists in Rome tested positive for the virus. One week later an Italian man repatriated to Italy from the city of Wuhan, China, was hospitalized and confirmed as the third case in Italy. Clusters of cases were later detected in Lombardy and Veneto on 21 February, with the first deaths on 22 February. By the beginning of March, there had been confirmed cases in all regions of Italy.

The COVID-19 pandemic in Kiribati was part of the worldwide pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus was confirmed to have reached Kiribati on 18 May 2021.

The COVID-19 pandemic in mainland China is part of the worldwide pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). China was where the first COVID outbreak occurred, the first where authorities imposed drastic measures in response (including lockdowns and face mask mandates), and was one of the first countries to bring the outbreak under control, at least temporarily.

The 2019–2020 COVID-19 outbreak in mainland China was the first wave of the disease, and was first manifested as a cluster of mysterious pneumonia cases, mostly related to the Huanan Seafood Market in Wuhan, the capital of Hubei province. It was first reported to the local government on 27 December 2019 and published on 31 December. On 8 January 2020, a new coronavirus (SARS-CoV-2) was identified as the cause of the pneumonia by Chinese scientists. By 29 January, the virus was found to have spread to all provinces of mainland China.