Santa Ana (Spanish for 'Saint Anne') is a city in and the county seat of Orange County, California, United States. Located in the Greater Los Angeles region of Southern California, the city's population was 310,227 at the 2020 census. As of 2023, Santa Ana is the third most populous city in Orange County (after Anaheim and Irvine), the 14th-most populous city in California, and the 65th most populous city in the United States. Santa Ana is a major regional economic and cultural hub for the Orange Coast.
In 1810, the Spanish governor of California granted Rancho Santiago de Santa Ana to José Antonio Yorba. Following the Mexican War of Independence, the Yorba family rancho was enlarged, becoming one of the largest and most valuable in the region and home to a diverse Californio community. Following the American Conquest of California, the rancho was sold to the Sepúlveda family, who subsequently lost their land claim. In 1869, William H. Spurgeon then purchased the rancho and formally founded the modern city of Santa Ana.