Scintigraphy (from Latin scintilla, "spark"), also known as a gamma scan, is a diagnostic test in nuclear medicine, where radioisotopes attached to drugs that travel to a specific organ or tissue (radiopharmaceuticals) are taken internally and the emitted gamma radiation is captured by gamma cameras, which are external detectors that form two-dimensional images in a process similar to the capture of X-ray images. In contrast, SPECT and positron emission tomography (PET) form 3-dimensional images and are therefore classified as separate techniques from scintigraphy, although they also use gamma cameras to detect internal radiation. Scintigraphy is unlike a diagnostic X-ray where external radiation is passed through the body to form an image.
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👉 Scintigraphy in the context of Digital imaging
Digital imaging or digital image acquisition is the creation of a digital representation of the visual characteristics of an object, such as a physical scene or the interior structure of an object. The term is often assumed to imply or include the processing, compression, storage, printing and display of such images. A key advantage of a digital image, versus an analog image such as a film photograph, is the ability to digitally propagate copies of the original subject indefinitely without any loss of image quality.
Digital imaging can be classified by the type of electromagnetic radiation or other waves whose variable attenuation, as they pass through or reflect off objects, conveys the information that constitutes the image. In all classes of digital imaging, the information is converted by image sensors into digital signals that are processed by a computer and made output as a visible-light image. For example, the medium of visible light allows digital photography (including digital videography) with various kinds of digital cameras (including digital video cameras). X-rays allow digital X-ray imaging (digital radiography, fluoroscopy, and CT), and gamma rays allow digital gamma ray imaging (digital scintigraphy, SPECT, and PET). Sound allows ultrasonography (such as medical ultrasonography) and sonar, and radio waves allow radar. Digital imaging lends itself well to image analysis by software, as well as to image editing (including image manipulation).
Scintigraphy in the context of Single-photon emission computed tomography
Single-photon emission computed tomography (SPECT, or less commonly, SPET) is a nuclear medicine tomographic imaging technique using gamma rays. It is very similar to conventional nuclear medicine planar imaging using a gamma camera (that is, scintigraphy), but is able to provide true 3D information. This information is typically presented as cross-sectional slices through the patient, but can be freely reformatted or manipulated as required.
The technique needs delivery of a gamma-emitting radioisotope (a radionuclide) into the patient, normally through injection into the bloodstream. On occasion, the radioisotope is a simple soluble dissolved ion, such as an isotope of gallium(III). Usually, however, a marker radioisotope is attached to a specific ligand to create a radioligand, whose properties bind it to certain types of tissues. This marriage allows the combination of ligand and radiopharmaceutical to be carried and bound to a place of interest in the body, where the ligand concentration is seen by a gamma camera.