Satibarzanes (Old Persian: *Šyātibr̥zaⁿs; Ancient Greek: Σατιβαρζάνης Satibarzánēs; died 330 BC), a Persian, was satrap of Aria under Darius III, king of Persia.
In 330 BC, Alexander the Great, marching through the borders of Aria on his way from Hyrcania against the Parthians, was met at a city named Susia by Satibarzanes, who made submission to him, and was rewarded for it by the restoration of his satrapy. In order to prevent the commission of any hostilities against the Arians by the Macedonian troops which were following from the west, Alexander left behind with Satibarzanes forty horse-dartmen, under the command of Anaxippus. These, however, together with their commander, were soon after murdered by the satrap, who incited the Arians to rebel, and gathered his forces together at the city of Artacoana.