Santa Fe Trail in the context of "Santa Fe, New Mexico"

Independence is a city mostly in and one of two county seats of Jackson County, Missouri, United States. It is a satellite city of Kansas City, Missouri, and is the largest suburb on the Missouri side of the Kansas City metropolitan area. In 2020, it had a total population of 123,011, making it the fifth-most populous city in Missouri. A small part of the city extends into Clay County.

Independence is known as the "Queen City of the Trails" because it was a point of departure for the California, Oregon, and Santa Fe Trails. It is the hometown of U.S. President Harry S. Truman, with the Truman Presidential Library and Museum, and the gravesites of Truman and First Lady Bess Truman. The city is sacred to the Latter Day Saint movement, as the home of Joseph Smith's 1831 Temple Lot, and the headquarters of several Mormon denominations.

In the history of the United States, American pioneers built overland trails throughout the 19th century, especially between 1840 and 1847 as an alternative to sea and railroad transport. These settlers began to settle much of North America west of the Great Plains as part of the overland mass settlements of the mid-19th century. Settlers emigrating from the eastern United States did so with various motives, among them religious persecution and economic incentives, to move from their homes to destinations further west via routes such as the Oregon, California, and Mormon Trails. After the end of the Mexican–American War in 1848, vast new American conquests of territory again encouraged mass settlement. Legislations like the Donation Land Claim Act and significant events like the California Gold Rush further encouraged settlers to travel overland to the north.

Two major wagon-based transportation networks, one typically starting in Missouri and the other in the Mexican province of Santa Fe de Nuevo México, served the majority of settlers during the era of westward expansion. Three of the Missouri-based routes—the Oregon, California, and Mormon Trails—were collectively known as the Emigrant Trails. Historians have estimated at least 500,000 emigrants used these three trails between 1843 and 1869, and despite growing competition from transcontinental railroads, some use even continued into the early 20th century. The major southern routes were the Santa Fe, Southern Emigrant, and Old Spanish Trails, as well as its wagon road successor the Mormon Road, a southern spur of the California Trail used in the winter that also made use of the western half of the Old Spanish Trail. Regardless of the trail used, the journey was often slow and arduous, fraught with risks from dysentry, infectious diseases, dehydration, malnutrition, cholera, highwaymen, Indian raids, injury, and harsh weather, with as many as one in ten travelers dying along the way, usually as a result of disease.

The Columbia metropolitan area is the region centered around the City of Columbia in the U.S. state of Missouri. Located in Mid-Missouri, it consists of five counties: Boone, Audrain, Randolph, Cooper, and Howard. The population was estimated at 256,640 in 2017, making it the 4th largest metropolitan area in Missouri. Columbia is home to the University of Missouri, and is Missouri's fourth most-populous and fastest growing city, with an estimated 121,717 residents as of 2017. Other significant cities in the area include Moberly, Mexico, Boonville, Vandalia, Centralia, and Fayette. There is also a 9-county Columbia–Jefferson City–Moberly combined statistical area with 415,747 residents.

The area was originally called the Boonslick and settled mainly by Kentuckians following the Boone's Lick Road starting around 1812. The town of Franklin, now washed into the Missouri River, was an early commercial center and start of the Santa Fe Trail. Columbia was founded as county seat of Boone County in 1821. The region was considered for the location of the Missouri State Capitol, but eventually a site was chosen 30 miles (48 km) south of Columbia and Jefferson City was created to serve that purpose. Today, Interstate 70, and U.S. Highways 63, 54, 24, and 40 link the urban areas. The U.S. census defines the Columbia MSA as Boone, Cooper, and Howard counties while the addition of the Jefferson City MSA along with Audrain and Randolph form the combined statistical area.