Santa Clara Valley in the context of "Sunnyvale, California"

Silicon Valley is a region in Northern California that is a global center for high technology and innovation. Located in the southern part of the San Francisco Bay Area, it corresponds roughly to the geographical area of the Santa Clara Valley. The term "Silicon Valley" refers to the area in which high-tech business has proliferated in Northern California, and it also serves as a general metonym for California's high-tech business sector.

The cities of Sunnyvale, Mountain View, Palo Alto and Menlo Park are frequently cited as the birthplace of Silicon Valley. Other major Silicon Valley cities are San Jose, Santa Clara, Redwood City and Cupertino. The San Jose Metropolitan Area has the third-highest GDP per capita in the world (after Zurich and Oslo), according to the Brookings Institution. As of June 2021, it also had the highest percentage of homes valued at $1 million or more in the United States.

San Jose, officially the City of San José (/ˌsæn hoʊˈzeɪ, -ˈseɪ/ SAN hoh-ZAY, -⁠SAY; Spanish: [saŋ xoˈse]), is a cultural, commercial, and political center within the San Francisco Bay Area and Silicon Valley. With a city population of 997,368 and a metropolitan area population of 1.95 million, it is the most populous city in both the Bay Area and Northern California and the 12th-most populous in the United States. Located in the center of the Santa Clara Valley on the southern shore of San Francisco Bay, San Jose covers an area of 179.97 sq mi (466.1 km) and is the county seat of Santa Clara County.

Before the arrival of the Spanish, the area around San Jose was long inhabited by the Tamien nation of the Ohlone people. San Jose was founded on November 29, 1777, as the Pueblo de San José de Guadalupe, the first city founded in the Californias. It became a part of Mexico in 1821 after the Mexican War of Independence. Following the U.S. Conquest of California during the Mexican–American War, the territory was ceded to the United States in 1848. After California achieved statehood two years later, San Jose served as the state's first capital. San Jose experienced an economic boom after World War II, with a rapid population growth and aggressive annexation of nearby communities in the 1950s and 1960s. The rapid growth of the technology industry in Silicon Valley further accelerated the city's transition from an agricultural center to an urbanized metropolitan area, prompting Mayor Tom McEnery to adopt San Jose's current motto, "Capital of Silicon Valley", in 1988. Results of the 1990 U.S. census indicated that San Jose had surpassed San Francisco in population. By the early 2000s, San Jose was California's fastest-growing economy.

The Salinas Valley (Spanish: Valle de Salinas) is one of the major valleys and most productive agricultural regions in California. It is located west of the San Joaquin Valley and south of San Francisco Bay and the Santa Clara Valley.

The Salinas River, which geologically formed the fluvial valley and generated its human history, flows to the northwest or 'up' along the principal axis and the length of the valley.

Cupertino (/ˌkuːpərˈtiːnoʊ/ KOOP-ər-TEEN-oh) is a city in Santa Clara County, California, United States, directly west of San Jose on the western edge of the Santa Clara Valley with portions extending into the foothills of the Santa Cruz Mountains. The population was 60,381 as of the 2020 census, decreasing by 1,671 (-2.9%) to a Census-estimated 58,710 by 2024. The city is the home of Apple Inc., headquartered at Apple Park.

Named for a local creek by Spanish explorer Juan Bautista de Anza's cartographer bearing the name of Saint Joseph of Cupertino, Cupertino was officially incorporated in 1955, though it saw economic activity in the early 19th century. The area was originally an agricultural community producing prunes, apricots and cherries, with a winery joining the ranks by the 19th century. Cupertino grew immensely during the 1950s due to the suburban housing boom experienced after the Second World War, concurring with the earliest roots of Silicon Valley developing near Cupertino. By the 1960s, office parks were being built and technology companies were setting up shop in the city, most notably Apple and Hewlett-Packard.

The Tamien people (also spelled Tamyen, Thamien, or Thámien) are one of eight linguistic divisions of the Ohlone people, who are groups of Native Americans who live in Northern California. The Tamien traditionally lived throughout the Santa Clara Valley. The use of the name Tamien is on record as early as 1777; it comes from the Ohlone name for the location of the first Mission Santa Clara (Mission Santa Clara de Thamien) on the Guadalupe River. Father Padres Tomás de la Peña mentioned in a letter to Junipero Serra that the area around the mission was called Thamien by the native people. The missionary fathers erected the mission on January 17, 1777, at the native village of So-co-is-u-ka.

Over 50 villages and tribes of the Ohlone (also known as Costanoan) Native American people have been identified as existing in Northern California circa 1769 in the regions of the San Francisco Peninsula, Santa Clara Valley, East Bay, Santa Cruz Mountains, Monterey Bay and Salinas Valley. The known tribe names and village locations of people who spoke the Costanoan languages are listed by regions below.

In 1925, Alfred Kroeber, then director of the Hearst Museum of Anthropology, declared the tribe extinct, which directly led to its losing federal recognition and land rights.