Samtskhe–Javakheti (Georgian: სამცხე-ჯავახეთი, [s̪ämt̪͡s̪ʰχe̞ d͡ʒäväχet̪ʰi], Armenian: Սամցխե-Ջավախեթի, romanized: Samts’khe-Javakhet’i) is a region (mkhare) in southern Georgia with a population of 147,400 (2023) and an area of 6,413 km (2,476 sq mi). The region has Akhaltsikhe as its administrative center. Samtskhe–Javakheti is made up of the historical Georgian provinces Meskheti, Javakheti and Tori.
The Baku-Tbilisi-Ceyhan oil pipeline, the South Caucasus natural gas pipeline, and the Kars–Tbilisi–Baku railway pass through the region.