Saint-Marc (French pronunciation: [sɛ̃ maʁk]; Haitian Creole: Sen Mak) is a commune in western Haiti in Artibonite departement. Its geographic coordinates are 19°7′N 72°42′W / 19.117°N 72.700°W. At the 2015 Census the commune had 266,642 inhabitants. It is one of the biggest cities, second to Gonaïves, between Port-au-Prince and Cap-Haïtien.
Before the settlement of the French, the region was known as Amani-y ad part of the Xaragua caciquat.