Generalbezirk Weißruthenien (Belarusian: Генеральная акруга Беларусь; lit. 'General District White Ruthenia') was an administrative subdivision of the Reichskommissariat Ostland of Nazi Germany that covered western Belarus from 1941 to 1944. It served as the Nazi civilian administration for the German occupation of Belarus during World War II, and supervised the collaborationist Belarusian Central Council of Radasłaŭ Astroŭski.
Wilhelm Kube was the Generalkommissar of Generalbezirk Weißruthenien until his death in 1943. Kube was succeeded by SS and Police Leader Curt von Gottberg who served as Generalkommissar for the remainder of its existence.