S-IVB in the context of Apollo 6

Skylab was the United States' first space station, launched by NASA, occupied for about 24 weeks between May 1973 and February 1974. It was operated by three trios of astronaut crews: Skylab 2, Skylab 3, and Skylab 4. Skylab was constructed from a repurposed Saturn V third stage (the S-IVB), and took the place of the stage during launch. Operations included an orbital workshop, a solar observatory, Earth observation and hundreds of experiments. Skylab's orbit eventually decayed and it disintegrated in the atmosphere on July 11, 1979, scattering debris across the Indian Ocean and Western Australia.

Apollo 4 (November 9, 1967), also known as SA-501, was the uncrewed first test flight of the Saturn V launch vehicle, the rocket that eventually took astronauts to the Moon. The space vehicle was assembled in the Vehicle Assembly Building, and was the first to be launched from Kennedy Space Center (KSC) in Florida, ascending from Launch Complex 39, where facilities built especially for the Saturn V had been constructed.

Apollo 4 was an "all-up" test, meaning all rocket stages and spacecraft were fully functional on the initial flight, a first for NASA. It was the first time the S-IC first stage and S-II second stage flew. It also demonstrated the S-IVB third stage's first in-flight restart. The mission used a Block I command and service module modified to test several key Block II revisions, including its heat shield at simulated lunar-return velocity and angle.

AS-203 (also known as SA-203 or Apollo 3) was an uncrewed flight of the Saturn IB rocket on July 5, 1966. It carried no command and service module, as its purpose was to verify the design of the S-IVB rocket stage restart capability that would later be used in the Apollo program to boost astronauts from Earth orbit to a trajectory towards the Moon. It achieved its objectives, but the S-IVB was inadvertently destroyed after four orbits during a differential pressure test that exceeded the design limits.

Several planned missions of the Apollo crewed Moon landing program of the 1960s and 1970s were canceled, for reasons which included changes in technical direction, the Apollo 1 fire, the Apollo 13 incident, hardware delays, and budget limitations. After the landing by Apollo 12, Apollo 20, which would have been the final crewed mission to the Moon, was canceled to allow Skylab to launch as a "dry workshop" (assembled on the ground in an unused S-IVB Saturn IB second stage). The next two missions, Apollos 18 and 19, were later canceled after Apollo 13 and further budget cuts. Two Skylab missions also ended up being canceled. Two complete Saturn V rockets remained unused and were put on display in the United States.