The Pueblo Revolt of 1680, also known as PopĂ©'s Rebellion or Po'pay's Rebellion, was an uprising of most of the Indigenous Pueblo people against the Spanish colonists in the province of Santa Fe de Nuevo MĂ©xico, larger than present-day New Mexico. Persistent Spanish policies, coupled with incidents of brutality and cruelty such as those that occurred in 1599 and resulted in the Ăcoma Massacre, stoked animosity and gave rise to the eventual Revolt of 1680. The persecution and mistreatment of Pueblo people who adhered to traditional religious practices was the most despised of these. Scholars consider it the first Native American religious traditionalist revitalization movement. The Spaniards were resolved to abolish pagan forms of worship and replace them with Christianity. The Pueblo Revolt killed 400 Spaniards and drove the remaining 2,000 settlers out of the province. The Spaniards returned to New Mexico twelve years later.