Ptolemy VI Philometor in the context of "Cleopatra II"

Satyrus (Ancient Greek: Σάτυρος) of Callatis was a distinguished Peripatetic philosopher and historian, whose biographies of famous people are frequently referred to by Diogenes Laërtius and Athenaeus. He came from Callatis Pontica, as was learned from a Herculaneum papyrus. He lived earlier than the reign of Ptolemy VI Philometor (181–146 BC) when his Lives were epitomized by Heraclides Lembus, probably during the 3rd century BC. Athenaeus frequently refers to him as a Peripatetic, but his connection to the Peripatetic school is otherwise unknown. His biographies dealt with many eminent people including kings (Dionysius the Younger, Philip), statesmen (Alcibiades), orators (Demosthenes), poets (Aeschylus, Sophocles, Euripides), and philosophers (Bias of Priene, Chilon of Sparta, Pythagoras, Empedocles, Zeno of Elea, Anaxagoras, Socrates, Diogenes, Anaxarchus, Stilpo). He also wrote on the population of Alexandria, and a work On Characters (Περὶ χαρακτήρων). Fragments of his biography of the Athenian dramatist Euripides were found at the end of a papyrus scroll discovered at Oxyrhynchus in the early twentieth century.

Alexander I Theopator Euergetes, surnamed Balas (Ancient Greek: Ἀλέξανδρος Βάλας, romanized: Alexandros Balas), was the ruler of the Seleucid Empire from 150 BC to August 145 BC. Picked from obscurity and supported by the neighboring Roman-allied Kingdom of Pergamon, Alexander landed in Phoenicia in 152 BC and started a civil war against Seleucid King Demetrius I Soter. Backed by mercenaries and factions of the Seleucid Empire unhappy with the existing government, he defeated Demetrius and took the crown in 150 BC. He married the princess Cleopatra Thea to seal an alliance with the neighboring Ptolemaic kingdom. His reign saw the steady retreat of the Seleucid Empire's eastern border, with important eastern satrapies such as Media being lost to the nascent Parthian Empire. In 147 BC, Demetrius II Nicator, the young son of Demetrius I, began a campaign to overthrow Balas, and civil war resumed. Alexander's ally, Ptolemaic king Ptolemy VI Philometor, moved troops into Coele-Syria to support Alexander, but then switched sides and threw his support behind Demetrius II. At the Battle of the Oenoparus River in Syria, he was defeated by Ptolemy VI and he died shortly afterward.

Ptolemy VII Neos Philopator (Greek: Πτολεμαῖος Νέος Φιλοπάτωρ, Ptolemaĩos Néos Philopátōr "Ptolemy the Father-loving [God]") was, ostensibly, a Ptolemaic king of Egypt. His identity and reign are controversial, and it is likely that he did not reign at all, but was only granted royal dignity posthumously. Depending on the historical reconstruction, he was a son of Cleopatra II of Egypt by either Ptolemy VI Philometor or Ptolemy VIII Physcon, with current scholarship leaning toward the second option.

The Battle of the Oenoparus took place in 145 BC on the Oenoparus river (the modern Afrin River, Syria) in the adjoining countryside of Antioch on the Orontes, the capital of the Seleucid Empire. It was fought between a coalition of Ptolemaic Egypt led by Ptolemy VI and Seleucids who favored the royal claim of Demetrius II Nicator against Seleucids who favored the claim of Alexander Balas. Both the Seleucid Empire and the Ptolemaic kingdom were diadochi, Greek-ruled successor states established after the conquests of Alexander the Great.

The Ptolemaic force won the battle, and Balas's hopes of securing the throne were ended. However, King Ptolemy VI suffered a mortal wound in the battle. Despite the Egyptian forces winning the battle, they too would be driven out of Syria by the now unified Seleucid Empire under Demetrius II, which turned on the leaderless Egyptian force and drove them out of Seleucid territory.