Nabarzanes (died c. 330 BC) was a high-ranking Persian commander, who served as the chiliarch of the royal cavalry of the Achaemenid King of Kings Darius III (r. 336–330 BC).
Following the Persian defeat against the Macedonian king Alexander the Great (r. 336–323 BC) at the Battle of Gaugamela in 331 BC, Nabarzanes conspired against Darius III with other Persian grandees, such as Bessus, the satrap of Bactria, and Barsaentes, the satrap of Arachosia-Drangiana. Together they arrested Darius III in mid-330 BC, with Bessus being chosen as the leader of the Achaemenid forces, probably due to his Achaemenid descent. The arrest of Darius III gave Alexander the pretext of avenging him. Fleeing from the pursuing Macedonian forces, Bessus and the rebels carried Darius III in a covered wagon, reportedly in golden chains. In order to buy some time for their escape, Bessus and his co-conspirators killed Darius III and left his body by the road. Bessus then appointed Nabarzanes the satrap of Hyrcania and Parthia, which were under one administrative unit. When Alexander approached Nabarzanes, he surrendered and was pardoned with the help of Bagoas. Nabarzanes then went back to Hyrcania, but was arrested by Phrataphernes, who had him sent to Alexander, where he was seemingly executed.