The prehistory of Mesopotamia is the period between the Paleolithic and the emergence of writing in the area of the Fertile Crescent around the Tigris and Euphrates rivers, as well as surrounding areas such as the Zagros foothills, southeastern Anatolia, and northwestern Syria.
In general, Paleolithic Mesopotamia is poorly documented, with the situation worsening in southern Mesopotamia for periods prior to the 4th millennium BC. Geological conditions meant that most of the remains were buried under a thick layer of alluvium or submerged beneath the waters of the Persian Gulf. The Middle Paleolithic witnessed the emergence of a population of hunter-gatherers who lived in the caves of the Zagros and, seasonally, in numerous open-air sites. They were producers of a lithic industry of the Mousterian type, and their funerary remains, found in the cave of Shanidar, indicate the existence of solidarity and the practice of healing between the members of a group. During the Upper Paleolithic, the Zagros was probably occupied by modern man. The Shanidar cave contains only tools made of bone or antler, typical of a local Aurignacian called "Baradostian" by specialists.