Pope Alexander VI in the context of "Rex Catholicissimus"

The four Raphael Rooms (Italian: Stanze di Raffaello) form a suite of reception rooms in the Apostolic Palace, now part of the Vatican Museums, in Vatican City. They are famous for their frescoes, painted by Raphael and his workshop. Together with Michelangelo's Sistine Chapel ceiling frescoes, they are the grand fresco sequences that mark the High Renaissance in Rome.

The Stanze, as they are commonly called, were originally intended as a suite of apartments for Pope Julius II. He commissioned Raphael, then a relatively young artist from Urbino, and his studio in 1508 or 1509 to redecorate the existing interiors of the rooms entirely. It was possibly Julius' intent to outshine the apartments of his predecessor (and rival) Pope Alexander VI, as the Stanze are directly above Alexander's Borgia Apartment. They are on the second floor, overlooking the south side of the Belvedere Courtyard.

The Catholic Monarchs were Queen Isabella I of Castile (r. 1474–1504) and King Ferdinand II of Aragon (r. 1479–1516), whose marriage and joint rule marked the de facto unification of Spain. They were both from the House of Trastámara and were second cousins, as they were both descended from John I of Castile. To remove the obstacle that this consanguinity would otherwise have posed to their marriage under canon law, they were given a papal dispensation by Sixtus IV. They married on October 19, 1469, in the city of Valladolid; Isabella was 18 years old and Ferdinand a year younger. Most scholars generally accept that the unification of Spain can essentially be traced back to the marriage of Ferdinand and Isabella. Their reign was called by W.H. Prescott "the most glorious epoch in the annals of Spain."

Spain was formed as a dynastic union of two crowns rather than a unitary state, as Castile and Aragon remained separate kingdoms until the Nueva Planta decrees of 1707–1716. The court of Ferdinand and Isabella was constantly on the move in order to bolster local support for the crown from local feudal lords. The title of "Catholic King and Queen" was officially bestowed on Ferdinand and Isabella by Pope Alexander VI in 1494, in recognition of their defence of the Catholic faith within their realms.

The Treaty of Tordesillas, signed in Tordesillas, Spain, on 7 June 1494, and ratified in Setúbal, Portugal, divided the newly discovered lands outside Europe between the Kingdom of Portugal and the Crown of Castile, along a meridian 370 leagues or 2,100 kilometres (1,300 mi) west of the Cape Verde islands, off the west coast of Africa. That line of demarcation was about halfway between Cape Verde (already Portuguese) and the islands visited by Christopher Columbus on his first voyage (claimed for Castile and León), named in the treaty as Cipangu and Antillia (Cuba and Hispaniola).

The lands to the east would belong to Portugal and the lands to the west to Castile, modifying an earlier bull by Pope Alexander VI. The treaty was created on 7 June 1494, then ratified by Spain on 2 July 1494, by Portugal on 5 September 1494, and by Pope Julius II on 24 January 1506. The other side of the world was divided a few decades later by the Treaty of Zaragoza, signed on 22 April 1529, which specified the antimeridian to the line of demarcation specified in the Treaty of Tordesillas. Portugal and Spain largely respected the treaties, while the Indigenous peoples of the Americas did not acknowledge them.

Louis XII (27 June 1462 – 1 January 1515), also known as Louis of Orléans was King of France from 1498 to 1515 and King of Naples (as Louis III) from 1501 to 1504. The son of Charles, Duke of Orléans, and Marie of Cleves, he succeeded his second cousin once removed and brother-in-law, Charles VIII, who died childless in 1498.

Louis was the second cousin of King Louis XI, who compelled him to marry the latter's disabled and supposedly sterile daughter Joan. By doing so, Louis XI hoped to extinguish the Orléans cadet branch of the House of Valois. When Louis XII became king in 1498, he had his marriage with Joan annulled by Pope Alexander VI and instead married Anne, Duchess of Brittany, the widow of Charles VIII. This marriage allowed Louis to reinforce the personal Union of Brittany and France.

The Camino de Santiago (Latin: Peregrinatio Compostellana, lit. 'Pilgrimage of Compostela'; Galician: O Camiño de Santiago), or the Way of St. James in English, is a network of pilgrims' ways or pilgrimages leading to the shrine of the apostle James in the cathedral of Santiago de Compostela in Galicia in northwestern Spain, where tradition holds that the remains of the apostle are buried. Pilgrims follow its routes as a form of spiritual path or retreat for their spiritual growth. It is also popular with hikers, cyclists, and organized tour groups.

Created and established in the beginning of the 9th century following the discovery of the relics of Saint James the Great, the Way of St. James became a major pilgrimage route of medieval Christianity from the 10th century onwards. Following the end of the Granada War in 1492, under the reign of the Catholic Monarchs Ferdinand II of Aragon and Isabella I of Castile, Pope Alexander VI officially declared the Camino de Santiago to be one of the "three great pilgrimages of Christendom", along with Jerusalem and the Via Francigena to Rome.

The Borgia Apartments are a suite of rooms in the Apostolic Palace in the Vatican, adapted for personal use by Pope Alexander VI (Rodrigo de Borja). In the late 15th century, he commissioned the Italian painter Bernardino di Betto (Pinturicchio) and his studio to decorate them with frescoes.

The paintings and frescoes, which were executed between 1492 and 1494, drew on a complex iconographic program that used themes from medieval encyclopedias, adding an eschatological layer of meaning celebrating the supposedly divine origins of the Borgias. Five of the six apartments include frescoes painted in the vault. The upper register of the vaults contain paintings, while the lower registers are decorated with tapestries and gold. Recent cleaning of Pinturicchio's fresco The Resurrection has revealed a scene believed to be the earliest known European depiction of Native Americans, painted just two years after Christopher Columbus returned from the New World.

The House of Aviz (Portuguese: Casa de Avis [ɐˈviʃ]), also known as the Joanine Dynasty (Dinastia Joanina), was a dynasty of Portuguese origin which flourished during the Renaissance and the period of the Portuguese discoveries, when Portugal expanded its power globally.

The house was founded by King John I of Portugal, Grand-Master of the Order of Aviz and illegitimate son of King Pedro I (of the Portuguese House of Burgundy), who ascended to the throne after successfully pressing his claim during the 1383–1385 Portuguese interregnum. Aviz monarchs would rule Portugal through the Age of Discovery, establishing Portugal as a global power following the creation of the Portuguese Empire. In 1494, Pope Alexander VI divided the world under the dominion of Portugal and Spain with the Treaty of Tordesillas.

Inter caetera ('Among other [works]') was a papal bull issued by Pope Alexander VI on 4 May 1493, which granted to the Catholic Monarchs King Ferdinand II of Aragon and Queen Isabella I of Castile all lands to the "west and south" of a pole-to-pole line 100 leagues west and south of any of the islands of the Azores or the Cape Verde islands.

It remains unclear whether the pope intended a "donation" of sovereignty or an infeudation or investiture. Differing interpretations have been argued since the bull was issued, with some arguing that it was only meant to transform the possession and occupation of land into lawful sovereignty. Others, including the Spanish crown and the conquistadors, interpreted it in the widest possible sense, deducing that it gave Spain full political sovereignty.