Pope Adrian VI in the context of "Inquisition in the Netherlands"

The Order of Santiago (/ˌsɒntiˈɑːɡoʊ/; Spanish: Orden de Santiago [sanˈtjaɣo]) is a religious and military order founded in the 12th century. It owes its name to the patron saint of Spain, Santiago (St. James the Greater). Its initial objective was to protect the pilgrims on the Way of St. James, to defend Christendom and to remove the Muslim Moors from the Iberian Peninsula with the Reconquista. Entrance was not restricted to nobility of Spain exclusively, and some members have been Catholic Europeans from other parts of Europe. The Order's insignia is particularly recognisable and abundant in Western art.

With the culmination of the Reconquista and the death of the Grand Master Alonso de Cárdenas, the Catholic Monarchs incorporated the Order into the Spanish Crown, and the Pope Adrian VI forever united the office of Grand Master of Santiago to the Crown in 1523.

Pope Clement VII (Latin: Clemens VII; Italian: Clemente VII; born Giulio di Giuliano de' Medici; 26 May 1478 – 25 September 1534) was head of the Catholic Church and ruler of the Papal States from 19 November 1523 to his death on 25 September 1534. Deemed "the most unfortunate of the popes", Clement VII's reign was marked by a rapid succession of political, military, and religious struggles—many long in the making—which had far-reaching consequences for Christianity and world politics.

Elected in 1523 at the end of the Italian Renaissance, Clement came to the papacy with a high reputation as a statesman. He had served with distinction as chief advisor to Pope Leo X (1513–1521, his cousin), Pope Adrian VI (1522–1523), and commendably as gran maestro of Florence (1519–1523). Assuming leadership at a time of crisis, with the Protestant Reformation spreading, the Church nearing bankruptcy, and large foreign armies invading Italy, Clement initially tried to unite Christendom by making peace among the many Christian leaders then at odds. He later attempted to liberate Italy from foreign occupation, believing that it threatened the Church's freedom.

Jan van Scorel (1 August 1495 – 6 December 1562) was a Dutch painter, who played a leading role in introducing aspects of Italian Renaissance painting into Dutch and Flemish Renaissance painting. He was one of the early painters of the Romanist style who had spent a number of years in Italy, where he thoroughly absorbed the Italian style of painting. His trip to Italy coincided with the brief reign of the only Dutch pope in history, Adrian VI in 1522–23. The pope made him a court painter and superintendent of his collection of antiquities. His stay in Italy lasted from 1518 to 1524 and he also visited Nuremberg, Venice and Jerusalem. Venetian art had an important impact on the development of his style.

He differed from most Romanists in that he was a native of the northern Netherlands and not of Flanders and that he remained most of his life in the northern Netherlands. He settled permanently in Utrecht in 1530 and established a large workshop on the Italian model. The workshop mainly produced altarpieces, many of which were destroyed in the Reformation iconoclasm in the years just after his death. He also held clerical appointments. This did not stop him from having a long-time relationship with a mistress who may have modelled for some of his female figures.