Pearl River in the context of Cantonese people

The Pearl River Delta Metropolitan Region is the low-lying area surrounding the Pearl River estuary, where the Pearl River flows into the South China Sea. Referred to as the Guangdong–Hong Kong–Macao Greater Bay Area in official documents, the region is one of the most densely populated and urbanized regions in the world, and is considered a megacity by numerous scholars. It is currently the wealthiest region in Southern China and one of the wealthiest regions in China along with the Yangtze River Delta in Eastern China and Jingjinji in Northern China. Most of the region is part of the Pearl River Delta Economic Zone, which is a special economic zone of China.

The region is a megalopolis, and is at the southern end of a larger megalopolis running along the southern coast of China, which include metropolises such as Hong Kong, Shenzhen, Guangzhou, and Macao. The nine largest cities of the PRD had a combined population of 86 million in 2022; the PRD has become the largest urban area in the world in both size and population. The region's traditional language is Cantonese; in the late 20th century and the 21st century, due to the high inflow of migrant workers coming from other regions, Mandarin has gradually become a lingua franca.

Guangzhou is the capital and largest city of southern China's Guangdong province. Located on the Pearl River about 120 km (75 mi) northwest of Hong Kong and 145 km (90 mi) north of Macau, Guangzhou has a history of over 2,200 years and was a major terminus of the Silk Road.

The port of Guangzhou serves as transportation hub. Guangzhou is also one of China's three largest cities. For a long time, it was the only Chinese port accessible to most foreign traders. Guangzhou was captured by the British during the First Opium War and no longer enjoyed a monopoly after the war. Consequently it lost trade to other ports such as Hong Kong and Shanghai, but continued to serve as a major entrepôt. Following the Second Battle of Chuenpi in 1841, the Treaty of Nanking was signed between Sir Robert Peel on behalf of Queen Victoria and Lin Zexu on behalf of Emperor Xuanzong and ceded Hong Kong to the United Kingdom on 26 January 1841 after the agreement of the Convention of Chuenpi.

The Li River or Li Jiang (Chinese: 漓江; pinyin: Lí Jiāng) is the name for the upper reaches of the Gui River in northeastern Guangxi, China. It is part of the Xijiang River system in the Pearl River basin, flowing 164 kilometres (102 mi) from Xing'an County to Pingle County.

Dongguan is a prefecture-level city in central Guangdong Province, China. An important industrial city in the Pearl River Delta, Dongguan borders the provincial capital of Guangzhou to the north, Huizhou to the northeast, Shenzhen to the south, and the Pearl River to the west. It is part of the Pearl River Delta built-up (or metro) area with more than 65.57 million inhabitants as of the 2020 census spread over nine municipalities across an area of 19,870 square kilometers (7,670 sq mi).

Dongguan's city administration is considered especially progressive in seeking foreign direct investment. Dongguan ranks behind only Shenzhen, Shanghai and Suzhou in exports among Chinese cities, with $65.54 billion in shipments. It is also home to one of the world's largest shopping malls, the New South China Mall, which is seeing increased activity. Although the city is geographically and thus culturally Cantonese in the Weitou form and as well as culturally Hakka in the prefectures of Fenggang and Qingxi, the majority of the modern-day population speaks Mandarin due to the large influx of economic migrants from other parts of China. The city is home to several universities, including Guangdong University of Science and Technology, Guangdong Medical University and Dongguan University of Technology.

The Xi River (/ʃiː/; Chinese: 西江) or Si-Kiang is the western tributary of the Pearl River in southern China. It is formed by the confluence of the Gui and Xun Rivers in Wuzhou, Guangxi. It originates from the eastern foot of the Maxiong Mountain in Qujing City, Yunnan Province. Then it flows east through Guangdong, and enters the Pearl River Delta just east of the Lingyang Gorge in Zhaoqing. The main branch of the Xi River flows southeast through the delta entering the South China Sea at Modao Men, just west of Macau. The major cities along the Xi include Wuzhou, Zhaoqing, and Jiangmen.

The other two main tributaries of Pearl River are the Dong River (literally, the East River) and Bei River (the Northern River). As for other functions, it plays a vital role in carbon storage and transport in Southern China. The Xi River is facing some ecological challenges such as drought, invasive species, and pollution.

The term Chinese Riviera is used for several premier tourist destinations in China (including Hong Kong and Macau) near the Canton River in South China:

• Coastal areas in the city of Zhuhai, Guangdong Province.
• The south-eastern coast of Hainan, from Haitang Bay in Sanya to Xiangshuiwan (香水湾, Perfume Bay) in Lingshui Li.