Khayr al-Nisa Begum (Persian: خیرالنساء بیگم; known under the royal title Mahd-i Ulya (مهد علیا), "the highest-ranked cradle"; died 26 July 1579) was an Iranian Mazandarani princess from the Marashi dynasty, who was the wife of the Safavid shah (king) Mohammad Khodabanda (r. 1578–1587) and mother of Abbas I. During the early part of her husband's reign, she was a powerful political figure in her own right and governed Iran de facto between February 1578 and July 1579. She gained power with the assassination of Pari Khan Khanum.
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Pari Khan Khanum in the context of Ismail II
Ismail II (Persian: اسماعیل دوم; born Ismail Mirza; 31 May 1537 – 24 November 1577) was the third shah of Safavid Iran from 1576 to 1577. He was the second son of Tahmasp I with his principal consort, Sultanum Begum of the Mawsillu clan of the Aq Qoyunlu confederation. On the orders of Tahmasp, Ismail spent twenty years imprisoned in Qahqaheh Castle; whether for his recurrent conflicts with the realm's influential vassals, or for his growing popularity with the Qizilbash tribes, resulting in Tahmasp becoming wary of his son's influence.
Tahmasp died In 1576 without a designated heir. Ismail, with the support of his sister, Pari Khan Khanum, overcame his opponents and usurped the crown. In order to relieve himself of potential claimants, Ismail purged all the male members of the royal family, except for his full-brother, Mohammad Khodabanda and his three sons. In fear of the Qizilbash influence on the administration and the army, Ismail replaced them with people whom he trusted. Ismail belittled the Shi'ia Islam scholars and sought spiritual guidance from the Sunni Islam ulama. This was perhaps out of spite for his father, who was a devoted Shi'ia.