Panamá Province in the context of Chiriquí Province

Panama City, also known as Panama, is the capital and largest city of the Republic of Panama. It has a total population of 410,354 in the city proper and 1,086,990 in the Panama District, which includes the outer corregimientos of the city. The metropolitan area has over 2,100,000 people. The city is located at the Pacific entrance of the Panama Canal, in the province of Panama. The city is the political and administrative center of the country, as well as a hub for banking and commerce.

The city of Panama was founded on 15 August 1519, by Spanish conquistador Pedro Arias Dávila. The city was the starting point for expeditions that conquered the Inca Empire of Peru. It was a stopover point on one of the most important trade routes in the American continent, leading to the fairs of Nombre de Dios and Portobelo, through which passed most of the gold and silver that Spain mined from the Americas.

Darién (UK: /ˈdɛəriən, ˈdær-/, US: /ˌdɛəriˈɛn, ˌdɑːr-, dɑːrˈjɛn/; Spanish: [daˈɾjen]) is a province in Panama whose capital city is La Palma. With an area of 11,896.5 km (4,593.3 sq mi), it is located at the eastern end of the country and bordered to the north by the province of Panamá and the region of Kuna Yala. To the south, it is bordered by the Pacific Ocean and Colombia. To the east, it borders Colombia; to the west, it borders the Pacific Ocean and the province of Panama.

The area surrounding the border with Colombia is known as the Darién Gap, a large swath of undeveloped swampland and forest. With no roads, it is the missing link of the Pan-American Highway.

Panamá is a district (distrito) of Panamá Province in Panama. The population according to the 2010 census was 880,691; the latest official estimate (for 2019) is 1,183,333. The district covers a total area of 2,031 km. The district seat is Panama City.