Paleogenetics in the context of "Genetics"

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⭐ Core Definition: Paleogenetics

Paleogenetics is the study of the past through the examination of preserved genetic material from the remains of ancient organisms. Emile Zuckerkandl and Linus Pauling introduced the term in 1963, long before the sequencing of DNA, in reference to the possible reconstruction of the corresponding polypeptide sequences of past organisms. The first sequence of ancient DNA, isolated from a museum specimen of the extinct quagga, was published in 1984 by a team led by Allan Wilson.

Paleogeneticists do not recreate actual organisms, but piece together ancient DNA sequences using various analytical methods. Fossils are "the only direct witnesses of extinct species and of evolutionary events" and finding DNA within those fossils exposes tremendously more information about these species, potentially their entire physiology and anatomy.

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👉 Paleogenetics in the context of Genetics

Genetics is the study of genes, genetic variation, and heredity in organisms. It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene.

Trait inheritance and molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the cell, the organism (e.g. dominance), and within the context of a population. Genetics has given rise to a number of subfields, including molecular genetics, epigenetics, population genetics, and paleogenetics. Organisms studied within the broad field span the domains of life (archaea, bacteria, and eukarya).

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Paleogenetics in the context of Indo-European migrations

The Indo-European migrations are hypothesized migrations of peoples who spoke Proto-Indo-European (PIE) and the derived Indo-European languages, which took place from around 4000 to 1000 BCE, potentially explaining how these related languages came to be spoken across a large area of Eurasia, spanning from the Indian subcontinent and Iranian plateau to Atlantic Europe.

While these early languages and their speakers are prehistoric (lacking documentary evidence), a synthesis of linguistics, archaeology, anthropology and genetics has established the existence of Proto-Indo-European and the spread of its daughter dialects through migrations of large populations of its speakers, as well as the recruitment of new speakers through emulation of conquering elites. Comparative linguistics describes the similarities between various languages governed by laws of systematic change, which allow the reconstruction of ancestral speech (see Indo-European studies). Archaeology traces the spread of artifacts, habitations, and burial sites presumed to be created by speakers of Proto-Indo-European in several stages, from their hypothesized Proto-Indo-European homeland to their diaspora throughout Western Europe, Central Asian, and South Asia, with incursions into East Asia. Recent genetic research, including paleogenetics, has increasingly delineated the kinship groups involved in this movement.

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Paleogenetics in the context of Svante Pääbo

Svante Pääbo ForMemRS KmstkNO (Swedish: [ˈsvânːtɛ̂ ˈpʰɛ̌ːbʊ̂]; born 20 April 1955) is a Swedish geneticist and Nobel Laureate who specialises in the field of evolutionary genetics. As one of the founders of paleogenetics, he has worked extensively on the Neanderthal genome. In 1997, he became founding director of the Department of Genetics at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany. Since 1999, he has been an honorary professor at Leipzig University; he currently teaches molecular evolutionary biology at the university. He is also an adjunct professor at Okinawa Institute of Science and Technology, Japan.

In 2022, he was awarded the Nobel Prize in Physiology or Medicine "for his discoveries concerning the genomes of extinct hominins and human evolution".

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