PGM-19 Jupiter in the context of "Cuban Missile Crisis"

Animals in space originally served to test the survivability of spaceflight, before human spaceflights were attempted. Later, many species were flown to investigate various biological processes and the effects microgravity and space flight might have on them. Bioastronautics is an area of bioengineering research that spans the study and support of life in space. To date, seven national space programs have flown non-human animals into space: the United States, Soviet Union, France, Argentina, China, Japan and Iran.

A wide variety of non-human animals have been launched into space, including monkeys and apes, dogs, cats, tortoises, mice, rats, rabbits, fish, frogs, spiders, insects, and quail eggs (which hatched on Mir in 1990). The US launched the first Earthlings into space, with fruit flies surviving a 1947 flight, followed by primates in 1949. The Soviet space program launched multiple dogs into space, with the first sub-orbital flights in 1951, and first orbital flights in 1957.

The PGM-17A Thor was the first operative ballistic missile of the United States Air Force (USAF). It was named after the Norse god of thunder. It was deployed in the United Kingdom between 1959 and September 1963 as an intermediate-range ballistic missile (IRBM) with thermonuclear warheads. Thor was 65 feet (20 m) in height and 8 feet (2.4 m) in diameter.

The first generation of Thor missiles were rushed into service, and design mistakes resulted in a 24% launch failure rate. The competing PGM-19 Jupiter missile saw more use, but both were quickly eclipsed by the Air Force's long range ICBM program, which could be fired from U.S. soil. By 1959, with the Atlas missile well on its way to operational status, both Thor and Jupiter programs became obsolete as delivery vehicles, yet continued to be built and deployed until 1963 for political reasons and to maintain aerospace industry employment.

The Juno I was a four-stage American space launch vehicle, used to launch lightweight payloads into low Earth orbit. The launch vehicle was used between January 1958 to December 1959. The launch vehicle is a member of the Redstone launch vehicle family, and was derived from the Jupiter-C sounding rocket. It is commonly confused with the Juno II launch vehicle, which was derived from the PGM-19 Jupiter medium-range ballistic missile. In 1958, a Juno I launch vehicle was used to launch America's first satellite, Explorer 1.

Juno II was an American space launch vehicle used during the late 1950s and early 1960s. It was derived from the Jupiter missile, which was used as the first stage.

The Rocketdyne S-3D (Air Force designation LR79) was an American liquid rocket engine produced by Rocketdyne (a division of North American Aviation) between 1956 and 1961. It was a gas generator, pump-fed engine, using a liquid oxygen (LOX) and RP-1 (kerosene) propellant combination, capable of producing 134,908 pounds of thrust (600.1 kN) at sea level.

The S-3 was based on the Redstone engine, and is part of the LR79 family, used on the PGM-19 Jupiter and PGM-17 Thor missiles, and on the Juno II rocket. Other members of the LR79 engine family include: XLR71-NA-1, B-2C, XLR83-NA-1, LR79-7, S-3D, XLR89-1, MB-3-1, X-1, LR83-NA-1, H-1, LR89-5, XLR89-5, S-3, LR89-7, MB-3-J, MB-3, MB-3-3, RZ.2, H-1c, H-1b, RS-27, RS-27A R, RS-56-OBA and RS-27C.

The W49 was an American thermonuclear warhead, used on the Thor, Atlas, Jupiter, and Titan I ballistic missile systems. W49 warheads were manufactured starting in 1958 and were in service until 1965, with a few warheads being retained until 1975.

The weapon itself was a Mark 28 Y1 warhead modified for the missile role.

The UGM-27 Polaris missile was a two-stage solid-fueled nuclear-armed submarine-launched ballistic missile (SLBM). As the United States Navy's first SLBM, it served from 1961 to 1980.

In the mid-1950s the Navy was involved in the Jupiter missile project with the US Army, and had influenced the design by making it squat so it would fit in submarines. However, they had concerns about the use of liquid fuel rockets on board ships, and some consideration was given to a solid fuel version, Jupiter S. In 1956, during an anti-submarine study known as Project Nobska, Edward Teller suggested that very small hydrogen bomb warheads were possible. A crash program to develop a missile suitable for carrying such warheads began as Polaris, launching its first shot less than four years later, in February 1960.