Otto III, Holy Roman Emperor in the context of "Crown of Bolesław I the Brave"

The Basilica of St. Bartholomew on the Island (Italian: Basilica di San Bartolomeo all'Isola, Latin: Basilica S. Bartholomaei in Insula) is a titular minor basilica, located in Rome, Italy. It was founded in 998 by Otto III, Holy Roman Emperor and contains the putative relics of St. Bartholomew the Apostle. It is located on Tiber Island, on the site of the former temple of Aesculapius, which had cleansed the island of its former ill-repute among the Romans and established its reputation as a hospital, continued under Christian auspices today.

Its cardinal priest has been Cardinal Blase Cupich since 19 November 2016.

The Ottonian Renaissance was a renaissance of Byzantine and Late Antique art in Central and Southern Europe that accompanied the reigns of the first three Holy Roman Emperors of the Ottonian (or Saxon) dynasty: Otto I (936–973), Otto II (973–983), and Otto III (983–1002), and which in large part depended upon their patronage. The leading figures in this movement were Pope Sylvester II and Abbo of Fleury. Renewed contact between the Ottonian court and Byzantine Constantinople spurred the hybridisation of Eastern-Byzantine and Western-Latin cultures, particularly in arts, architecture and metalwork, while the Ottonians revitalised the cathedral school network which promoted learning based on the seven liberal arts. Ottonian intellectual activity was largely a continuation of Carolingian works, but circulated mainly in the cathedral schools and the courts of bishops (such as Liège, Cologne and Magdeburg), rather than the royal court.

The Bamberg Apocalypse (Bamberg State Library, Msc.Bibl.140) is an 11th-century richly illuminated manuscript containing the pictorial cycle of the Book of Revelation and a Gospel Lectionary of the books of pericopes. This medieval illuminated manuscript was created during the Ottonian dynasty; was probably commissioned by Otto III, although, by less accounts, Henry II. It was completed sometime between 1000 and 1020. There is proof that Henry II donated this illuminated manuscript in 1020 to Collegiate Abbey of St. Stephan, on the occasion of its inauguration. The Bamberg Apocalypse is now located in the Bamberg State Library.

The 1000s was a decade of the Julian Calendar which began on January 1, 1000, and ended on December 31, 1009.

• Palace Scandal: Princess Consort Yasuko has an affair. Michinaga (her half-brother) investigates it secretly and finds out the truth about her pregnancy. Yasuko cries and repents. Yasuko leaves the palace under the patronage of Empress Dowager Senshi and Michinaga (moved to his residence).
• Murasaki Shikibu starts to write The Tale of Genji.
• Ichimonjiya Wasuke, the oldest surviving wagashi store, is established as a teahouse adjacent to Imamiya Shrine.
• January 10: Death of Empress Dowager Masako (empress consort of the late Emperor Reizei)
• April 8: Fujiwara no Shoshi is promoted to Empress (Chugu), while there is another empress, Fujiwara no Teishi (kogo) - this is the first time that there are two empresses

• The Taíno have become the dominant culture of modern day Puerto Rico.

The Muslim world was in its Golden Age; still organised in caliphates, it continued to be dominated by the Abbasid Caliphate, with the Caliphate of Córdoba to the west, the Fatimid Caliphate in North Africa, and experienced ongoing campaigns in Africa and in India. At the time, Persia was in a period of instability, with various polities seceding from Abbasid rule, among whom the Ghaznavids would emerge as the most powerful.

The Vienna Coronation Gospels, also known simply as the Coronation Gospels (German: Krönungsevangeliar), is a late 8th century illuminated gospel book produced at the court of Charlemagne in Aachen. It was used by the future emperor at his coronation on Christmas Day 800, when he placed three fingers of his right hand on the first page of the Gospel of Saint John and took his oath. Traditionally, it is considered to be the same manuscript that was found in the tomb of Charlemagne when it was opened in the year 1000 by Emperor Otto III. The Coronation Evangeliar cover was created by Hans von Reutlingen, c. 1500. The Coronation Evangeliar is part of the Imperial Treasury (Schatzkammer) in the Hofburg Palace in Vienna, Austria (Schatzkammer, Inv. XIII 18).

The Liuthar Gospels (also Gospels of Otto III or Ottonian Gospels) are a work of Ottonian illumination which are counted among the masterpieces of the period known as the Ottonian Renaissance. The manuscript, named after a monk called Liuthar, was probably created around the year 1000 at the order of Otto III at the Abbey of Reichenau and lends its name to the Liuthar Group of Reichenau illuminated manuscripts. The backgrounds of all the images are illuminated in gold leaf, a seminal innovation in western illumination.

After the French Revolution, the manuscript fell to private property and was only returned in 1848.