Omonoia Square in the context of "Patission Avenue"

Patision Street (also Patission; Greek: Οδός Πατησίων) is one of the major streets in central Athens, Greece. Though it is known as Patision, its name for its stretch between Panepistimiou Street and Amerikis Square, was changed to 28 October Street, commemorating the day in 1940 that the Greek dictator Ioannis Metaxas refused the Italian dictator Benito Mussolini's ultimatum that Greece submit to Italian control, thus starting the Greco-Italian War.

Patision Street connects the area known as Patisia with Omonoia Square in the center of Athens. It is crowded by bus and trolley bus lines, which connect the city center with Kypseli (trolley lines 2, 4, 9), Lamprini [el] (trolley lines 5, 13, 14), Patisia (trolley line 11), Nea Filadelfeia (trolley line 3), Perissos [el] (bus lines 605, 054), Marousi (bus line A8) and Galatsi (bus line 608). It is a southbound one-way route with a northbound bus lane until it meets Marnis street, and it has three lanes per direction until Amerikis Square.

Panepistimiou Street (Greek: Οδός Πανεπιστημίου, "University Street", named after the University of Athens, the central building of which is on the upper corner) is a major street in Athens that has run one way for non-transit vehicles since 2002 from Vasilissis Amalias Avenue, Syntagma Square and Vassilissis Sofias Avenue to Omonoia Square in which is now a pedestrian crossing and before an intersection. Its total length is about 1.2 km. The street was formally renamed as Eleftherios Venizelos Avenue in 1945 (after the famous Prime Minister) but is still usually known by its historical name. It has six lanes, of which five are for traffic and one eastbound lane for transit buses only. Most of the street runs almost diagonally from southeast to northwest.

Buildings along the street include the Bank of Greece, Athens Eye Clinic, the University of Athens, the Academy of Athens, the National Library, the Numismatic Museum, Titania Hotel, Attica Department Store, as well as a part of the Grande Bretagne Hotel and the Catholic Cathedral of Athens. Many buildings as high as ten to fifteen stories line this street. Old neoclassical buildings of no higher than two to three stories used to exist until the 1950s, when a construction spree, which lasted several decades, demolished all but a few of them.