Nueces County (/njuˈeɪsɪs/ new-AY-siss) is located in the southern part of the U.S. state of Texas. As of the 2020 census, the population was 353,178, making it the 16th-most populous county in the state. The county seat is Corpus Christi, which is also the most populous city in the Nueces County, at 317,773 people, as of 2021. The county was formed in 1846 from portions of San Patricio County and organized the following year. It is named for the Nueces River, which marks the county's northwestern boundary with San Patricio County before emptying into its mouth at Nueces Bay north of the port of Corpus Christi. Nueces County is part of the Corpus Christi metropolitan statistical area.