Nisibis in the context of "School of Nisibis"

The School of Edessa (Syriac: ܐܣܟܘܠܐ ܕܐܘܪܗܝ) was a Christian theological school of great importance to the Syriac-speaking world. It had been founded as long ago as the 2nd century by the kings of the Abgar dynasty. In 363, Nisibis fell to the Persians, causing St. Ephrem the Syrian, accompanied by a number of teachers, to leave the School of Nisibis. They went to Edessa, where Ephrem took over the directorship of its school. Then, its importance grew still further. There were innumerable monasteries at Edessa housing many monks. Ephrem occupied a cell there, practicing the ascetic life, interpreting Holy Scripture, composing poetry and hymns and teaching in the school, as well as instructing young girls in church music.

The first recorded director of the School of Edessa was Qiiore, in the early 5th century. He had ascetic and scholarly qualifications and an administrative ability. Occupying the Chair of Exegesis (mepasqana), he replaced the texts of Ephraim with those of Theodore of Mopsuestia. With that seminal decision, Qiiore embarked upon a course of study that was to mix the deductive principles of Aristotle with Theodore's Dyophysite creed.

The Treaty of Dara, also known as the Fifty-Year Peace, was a peace treaty concluded between the Byzantine (Eastern Roman) and Sassanid (Persian) empires at the frontier town of Dara in what is now southern Turkey in 562. The treaty, negotiated by Peter the Patrician for the Byzantine emperor Justinian I and Izadgushasp for the Sassanid king Khosrau I ended the 20-year-long war over the Caucasian kingdom of Lazica. The treaty contained 13 articles, and is well-recorded. It covered all parts of the two empires, Persarmenia, Lazica, the client states, and the Arab allies.

The Sassanids undertook to evacuate Lazica, but the status of the neighboring country of Suania was left unclear to become a future source of disagreement. The Sassanids were to receive an annual subsidy of 30,000 gold nomismata, with the first seven years payable immediately. The expenses of the defense lines in the Caucasus against the nomads in the north, for which there was a mutual interest and had been the responsibility of the Sasanians, were included in the payments. Both sides agreed not to establish new fortifications or fortify the existing settlements on the border. To prevent spying, trade was restricted to Callinicum, Nisibis, and Dvin, while traders from other nations were restricted to Dara (under the Byzantines) and Nisibis (under the Sasanians). Refugees were free to return to their homes. In a separate treaty, the Christians in the Sasanian Empire were promised freedom of religion.

Adiabene (Greek: Αδιαβηνή, Classical Syriac: ܚܕܝܐܒ) was an ancient kingdom in northern Mesopotamia, corresponding to the northwestern part of ancient Assyria. The size of the kingdom varied over time; initially encompassing an area between the Zab Rivers, it eventually gained control of Nineveh and starting at least with the rule of Monobazos I (late 1st-century BCE), Gordyene became an Adiabenian dependency. It reached its zenith under Izates II, who was granted the district of Nisibis by the Parthian king Artabanus II (r. 12–40) as a reward for helping him regain his throne. Adiabene's eastern borders stopped at the Zagros Mountains, adjacent to the region of Media. Arbela served as the capital of Adiabene.

The formation of the kingdom is obscure. The first instance of a recorded Adiabenian ruler is in 69 BCE, when an unnamed king of Adiabene participated in the battle of Tigranocerta as an ally of the Armenian king Tigranes the Great (r. 95–55 BCE). However, coinage implies the establishment of a kingdom in Adiabene around 164 BCE, following the disintegration of Greek Seleucid rule in the Near East. Adiabene was conquered by the Parthian king Mithridates I (r. 171–132 BCE) between 145–141 BCE, and served at least from the reign of Mithridates II (r. 124–91 BCE) as an integral part of the Parthian realm.

Muḥammad Abū’l-Qāsim Ibn Ḥawqal (محمد أبو القاسم بن حوقل), also known as Abū al-Qāsim b. ʻAlī Ibn Ḥawqal al-Naṣībī, born in Nisibis, Upper Mesopotamia; was a 10th-century Arab Muslim writer, geographer, and chronicler who travelled from AD 943 to 969. His famous work, written in 977, is called Surat al-Ard (صورة الارض; "The face of the Earth"). The date of his death, known from his writings, was after AH 368/AD 978.

Ardabur (Greek: Ἀρδαβούρ) served as magister militum in the East Roman army in the 420s, under Theodosius II. He was of Alanic origin.

During the Roman-Persian War of 421–422, he ravaged Arzanene and besieged Nisibis. After the war ended, Ardabur was promoted to the rank of magister militum praesentalis.

Ephrem the Syrian (/ˈiːfrəm, ˈɛfrəm/; c. 306 – 373), also known as Ephraem the Deacon, Ephrem of Edessa or Aprem of Nisibis, (Syriac: ܡܪܝ ܐܦܪܝܡ ܣܘܪܝܝܐ — Mâr Aphrêm Sûryâyâ) was a prominent Syriac-Aramean Christian theologian and writer who is revered as one of the most notable hymnographers of Eastern Christianity. He was born in Nisibis, served as a deacon and later lived in Edessa.

Ephrem is venerated as a saint by all traditional Churches. He is especially revered in Syriac Christianity, both in East Syriac tradition and West Syriac tradition, and also counted as a Holy and Venerable Father (i.e., a sainted monk) in the Eastern Orthodox Church, especially in the Slovak tradition. He was declared a Doctor of the Church in the Catholic Church in 1920. Ephrem is also credited as the founder of the School of Nisibis, which in later centuries was the center of learning for the Church of the East.