Ninisina (Sumerian: "Mistress of Isin") was a Mesopotamian goddess who served as the tutelary deity of the city of Isin. She was considered a healing deity. She was believed to be skilled in the medical arts, and could be described as a divine physician or midwife. As an extension of her medical role, she was also believed to be capable of expelling various demons. Her symbols included dogs, commonly associated with healing goddesses in Mesopotamia, as well as tools and garments associated with practitioners of medicine.
While Ninisina was initially considered to be an unmarried and childless goddess, the god Pabilsag eventually came to be viewed as her husband. Her children were Damu and Gunura, like her considered to be healing deities, as well as Šumaḫ, who also served as her sukkal, a type of divine attendant. Further members of her court included Ninarali, a goddess associated with the underworld, harpist goddesses Ninigizibara and Ninḫinuna, and sometimes Ninshubur. Ninisina also developed associations with various other goddesses of similar character, including Ninkarrak, Gula and Nintinugga. However, while they were often considered analogous, they originated in different areas of Mesopotamia and their individual traits differed. A further goddess connected with her was Bau, who might have developed into a healing goddess because of the association between them. For political reasons, Ninisina also acquired some traits originally belonging to Inanna when the kings of Isin lost control over the cult center of the latter goddess, Uruk.