Niki, Greece

The Medžitlija-Níki border crossing linking North Macedonia with Greece is one of the three transit points for road vehicles between the two states. Situated about 190 km from Thessaloniki and the same to Skopje, it also once served as Yugoslavia's southernmost exit. It is located on the European route E65.

Despite linking the important city of Bitola with the regions of western Greece including Corfu and other holiday spots, it is the other crossing Evzoni-Bogorodica which is of greater significance as it forms a part of the E75 express route. The region around Medžitlija-Níki is far less developed on both sides of the border.

Greek National Road 3 (Greek: Εθνική Οδός 3, abbreviated as EO3) is a single carriageway road in Greece. It connects Elefsina near Athens with the border of North Macedonia at Niki. It passes through Larissa and Florina. At Niki, it connects with the M5K motorway to Bitola. The section Kozani - Niki is also designated as the A27 motorway, part of which is operational as a 2-lane motorway.

Greek National Road 3 is one of the longest national roads in Greece and until the 1960s it served as the main route from Larissa to Thessaloniki. The A1 motorway now offers a faster connection to Thessaloniki. Most of the EO3, except the southernmost section between Eleusis and Bralos, is part of the E65.

The A27 motorway is a branch of the A2 Egnatia Odos motorway at Kozani, which leads towards Ptolemaida and from there to Florina and the Niki border crossing with North Macedonia. It is part of the European route E65.

Within 2012 tenders were announced for the construction of the 14,5 km section from Florina up to the border crossing with North Macedonia as a motorway. Construction started in 2013 and finished in December 2015. The northern part from Florina to Niki was opened to traffic on 20 May 2016. The section from Ptolemaida to Florina is operational as an expressway (GR-3) and is planned to be upgraded to a motorway sometime until 2025.